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Perception of Agrobacterium tumefaciens flagellin by FLS2XL confers resistance to crown gall disease
Nature Plants ( IF 15.8 ) Pub Date : 2020-01-16 , DOI: 10.1038/s41477-019-0578-6
Ursula Fürst 1 , Yi Zeng 2 , Markus Albert 1 , Anna Kristina Witte 3 , Judith Fliegmann 1 , Georg Felix 1
Affiliation  

Bacterial flagella are perceived by the innate immune systems of plants1 and animals2 alike, triggering resistance. Common to higher plants is the immunoreceptor FLAGELLIN-SENSING 2 (FLS2)3, which detects flagellin via its most conserved epitope, flg22. Agrobacterium tumefaciens, which causes crown gall disease in many crop plants, has a highly diverged flg22 epitope and evades immunodetection by plants so far studied. We asked whether, as a next step in this game of ‘hide and seek’, there are plant species that have evolved immunoreceptors with specificity for the camouflaged flg22Atum of A. tumefaciens. In the wild grape species Vitis riparia, we discovered FLS2XL, a previously unknown form of FLS2, that provides exquisite sensitivity to typical flg22 and to flg22Atum. As exemplified by ectopic expression in tobacco, FLS2XL can limit crown gall disease caused by A. tumefaciens.



中文翻译:

FLS2XL对根癌农杆菌鞭毛蛋白的感知赋予了对冠瘿病的抵抗力

植物1和动物2的先天免疫系统都可以感知细菌鞭毛,从而引发抵抗力。高等植物共有的是免疫受体 FLAGELLIN-SENSING 2 (FLS2) 3,它通过其最保守的表位 flg22 检测鞭毛蛋白。在许多作物中引起冠瘿病的根癌农杆菌具有高度分化的flg22表位并且逃避迄今为止研究的植物的免疫检测。我们询问,作为这场“捉迷藏”游戏的下一步,是否有植物物种已经进化出对根癌农杆菌的伪装 fl​​g22 Atum 具有特异性的免疫受体。在野生葡萄品种Vitis riparia,我们发现了 FLS2 XL,这是一种以前未知的 FLS2 形式,它对典型的 flg22 和 flg22 Atum具有极高的敏感性。以烟草中的异位表达为例,FLS2 XL可以限制由根癌农杆菌引起的冠瘿病。

更新日期:2020-01-16
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