Abstract This study demonstrates a comprehensive and cost-effective one-step rapid bio-fabrication of Eucalyptus globulus leaf extract (ELE) bio-actives functionalized copper oxide nanoparticles (CuONPs); and analyze its apoptotic and toxic effects in human breast cancer (MCF-7) cells and Aspergillus flavus. The state-of-art characterization data confirmed the thermal-stability of (i) ELE-CuONPs and (ii) surface associated ELE bio-active compounds bearing characteristic functional groups (aromatic OH, polymeric OH, C O, and C O) over a range of conventional temperatures (30 °C–80 °C), and microwave (MW) heat (140 °C). The MW accelerated ELE-CuONPs (16.9 nm) treated (25−100 μg/ml) MCF-7 cells showed a significant (p

中文翻译：

---

生物功能化的 CuO 纳米颗粒诱导人乳腺癌细胞凋亡活动和对黄曲霉的毒性：一种体外方法

摘要 本研究展示了蓝桉叶提取物 (ELE) 生物活性物质功能化氧化铜纳米粒子 (CuONPs) 的全面且经济高效的一步式快速生物制造；并分析其在人乳腺癌（MCF-7）细胞和黄曲霉中的凋亡和毒性作用。最先进的表征数据证实了 (i) ELE-CuONPs 和 (ii) 表面相关的 ELE 生物活性化合物在一定范围内具有特征官能团（芳香族 OH、聚合 OH、CO 和 CO）的热稳定性常规温度 (30 °C–80 °C) 和微波 (MW) 加热 (140 °C)。MW 加速的 ELE-CuONPs (16.9 nm) 处理 (25-100 μg/ml) MCF-7 细胞显示出显着的 (p