Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation. Rapid progress in the field requires a focused update on the latest advances. Recent studies show that TFEB and TFE3 function in innate immune cells to regulate antibacterial and antiviral responses downstream of phagocytosis, interferon (IFN)-γ, lipopolysaccharide (LPS), and adenosine receptors. Moreover, overexpression of TFEB or TFE3 can drive inflammation in vivo, such as in atherosclerosis, while in other scenarios they can perform anti-inflammatory functions. MiT factors may constitute potential therapeutic targets for a broad range of diseases; however, to harness their therapeutic potential, sophisticated ways to manipulate MiT factor activity safely and effectively must be developed.

中文翻译：

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MiT 转录因子在先天免疫和炎症中的关键作用。


小眼/TFE (MiT) 转录因子 (TF)，例如转录因子 EB (TFEB) 和转录因子 E3 (TFE3)，正在成为先天免疫和炎症的关键调节因子。该领域的快速进展需要重点更新最新进展。最近的研究表明，TFEB 和 TFE3 在先天免疫细胞中发挥作用，调节吞噬作用、干扰素 (IFN)-γ、脂多糖 (LPS) 和腺苷受体下游的抗菌和抗病毒反应。此外，TFEB或TFE3的过度表达可以驱动体内炎症，例如在动脉粥样硬化中，而在其他情况下它们可以发挥抗炎功能。 MiT 因子可能构成多种疾病的潜在治疗靶点；然而，为了利用它们的治疗潜力，必须开发安全有效地操纵 MiT 因子活性的复杂方法。