A new and efficient cyclization reaction has been developed to synthesize cyclic α,α‐disubstituted β‐amino esters via iron‐catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O‐aminal under mild reaction conditions. A broad range of hydroxy‐α‐diazoesters with different substituents and various N,O‐aminals were compatible with this protocol, affording the corresponding α,α‐disubstituted β‐amino esters bearing a five‐ to eight‐membered oxacycle in good yields.

中文翻译：

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具有N，O-氨基的羟基α-重氮酸酯的铁催化氨甲基氧合环化反应

已开发出一种新的高效环化反应，通过在温和的反应条件下，通过铁催化的重氮化合物与N，O-氨基的重氮化合物的分子内氨基甲氧基加氧环化反应，合成环状α，α-二取代的β-氨基酯。各种具有不同取代基的羟基α-重氮酸酯和各种N，O-氨基缩醛与该方案兼容，从而以高收率提供了带有五至八元氧杂环的相应α，α-二取代的β-氨基酯。