MYORG mutation heterozygosity is associated with brain calcification,Movement Disorders

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MYORG mutation heterozygosity is associated with brain calcification
Movement Disorders ( IF 7.4 ) Pub Date : 2020-01-17 , DOI: 10.1002/mds.27973
You Chen _{1,

2} , Zhidong Cen _{1,

2} , Xinhui Chen ₁ , Haotian Wang _{1,

2} , Si Chen _{1,

2} , Dehao Yang _{1,

2} , Feng Fu _{1,

3} , Lebo Wang ₁ , Peng Liu _{1,

2} , Hongwei Wu ₄ , Xiaosheng Zheng ₅ , Fei Xie ₆ , Zhiyuan Ouyang ₁ , Yun Zhang ₁ , Yongji Zhou ₇ , Xuerong Huang ₈ , Feng Wang ₉ , Guangsu Huang ₁₀ , Hongwei An ₁₁ , Yubing Liang ₁₁ , Weijun Hong ₁₂ , Anli Wang ₁₃ , Shuangling Huang ₁₄ , Wenhai Chen ₁₅ , Lili Yin ₁₆ , Yan Yang _{17,

18} , Huayun Huang ₁₉ , Ruxin Zeng ₂₀ , Na Zhao ₂₁ , Biao Jiang ₂₂ , Baorong Zhang ₁ , Wei Luo ₁ ,

Affiliation

Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Neurology, Zhuji People's Hospital of Zhejiang Province, Shaoxing, Zhejiang, China.
Department of Neurology, Lishui People's Hospital, Lishui, Zhejiang, China.
Department of Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Neurology, Hangzhou Geriatric Hospital (Hangzhou First People's Hospital Chengbei branch), Hangzhou, Zhejiang, China.
Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Neurology, Taizhou Hospital, Taizhou, Zhejiang, China.
Department of Neurology, Liuzhou People's Hospital, Liuzhou, Guangxi, China.
Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, China.
Department of Neurology, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, Zhejiang, China.
Department of Neurology, Pujiang County People's Hospital, Jinhua, Zhejiang, China.
Department of Neurology, Liping Hospital of Chinese Traditional Medicine, Liping, Guizhou, China.
Department of Neurology, Liping County People's Hospital, Liping, Guizhou, China.
Department of Neurology, Sanmen People's Hospital, Taizhou, Zhejiang, China.
Neurology Department, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Geriatric Department, the Second Clinical Medicine College of Jining Medical University, Jining, Shandong, China.
Department of Neurology, Changxing County People's Hospital, Huzhou, Zhejiang, China.
Department of Neurology, Cangnan People's Hospital, Wenzhou, Zhejiang, China.
Department of Neurology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Wenzhou, Zhejiang, China.
Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Biallelic mutations in the MYORG gene were first identified as the cause of recessively inherited primary familial brain calcification. Interestingly, some heterozygous carriers also exhibited brain calcifications.

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