Advanced glycation end products (AGEs) have been implicated in the pathogenesis of most chronic diseases. Therefore, identification of treatments that can attenuate the effects of these compounds and prevent cardiometabolic complications is of extreme public health interest. Recently, body weight management interventions showed positive results on reducing serum AGE concentrations. Moreover, the soluble receptor for advanced glycation end products (sRAGE) is considered to be a novel biomarker to identify patients with obesity most likely to benefit from weight management interventions. This systematic review aimed to critically analyze papers evaluating the effects of weight loss on serum AGEs and its receptors in adults with excess body weight. MEDLINE, Cochrane, Scopus, and Lilacs databases were searched. Three studies evaluating the response of AGEs to energy‐restricted diets and six assessing sRAGE as the primary outcome were included. Energy‐restricted diets and bariatric surgery reduced serum AGE concentrations, but effects on endogenous secretory RAGE (esRAGE) and sRAGE concentrations are conflicting. These results may be associated with mechanisms related to changes in dietary intake and limiting endogenous AGE formation. Therefore, the role of energy‐restricted diets and bariatric surgery on lowering serum AGE concentrations, as well as its effects on AGEs receptors, deserves further investigation.

中文翻译：

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体重减轻会影响晚期糖基化终产物及其受体吗？系统的审查。

晚期糖基化终产物（AGEs）已与大多数慢性疾病的发病机理有关。因此，鉴定能够减弱这些化合物的作用并预防心脏代谢并发症的治疗方法具有极大的公共卫生意义。最近，体重管理干预措施在降低血清AGE浓度方面显示出积极的结果。此外，晚期糖基化终产物的可溶性受体（sRAGE）被认为是一种新型的生物标志物，可用于识别最有可能从体重管理干预中受益的肥胖患者。这项系统的综述旨在严格分析评估体重减轻对成年人体重过重成年人血清AGEs及其受体的影响的论文。搜索MEDLINE，Cochrane，Scopus和Lilacs数据库。包括三项评估AGEs对能量受限饮食的反应的研究，以及六项评估sRAGE作为主要结果的研究。能量受限的饮食和减肥手术降低了血清AGE浓度，但对内源性分泌RAGE（esRAGE）和sRAGE浓度的影响存在矛盾。这些结果可能与饮食摄入变化和限制内源性AGE形成的机制有关。因此，节食饮食和减肥手术对降低血清AGE浓度的作用及其对AGEs受体的影响值得进一步研究。但是对内源性分泌RAGE（esRAGE）和sRAGE浓度的影响是矛盾的。这些结果可能与饮食摄入变化和限制内源性AGE形成的机制有关。因此，节食饮食和减肥手术对降低血清AGE浓度的作用及其对AGEs受体的影响值得进一步研究。但是对内源性分泌RAGE（esRAGE）和sRAGE浓度的影响是矛盾的。这些结果可能与饮食摄入变化和限制内源性AGE形成的机制有关。因此，节食饮食和减肥手术在降低血清AGE浓度及其对AGEs受体的影响方面的作用值得进一步研究。