The mechanisms behind molecular transport from cerebrospinal fluid to dural lymphatic vessels remain unknown. This study utilized magnetic resonance imaging along with cerebrospinal fluid tracer to visualize clearance pathways to human dural lymphatics in vivo. In 18 subjects with suspicion of various types of cerebrospinal fluid disorders, 3D T2-Fluid Attenuated Inversion Recovery, T1-black-blood, and T1 gradient echo acquisitions were obtained prior to intrathecal administration of the contrast agent gadobutrol (0.5 ml, 1 mmol/ml), serving as a cerebrospinal fluid tracer. Propagation of tracer was followed with T1 sequences at 3, 6, 24 and 48 h after the injection. The tracer escaped from cerebrospinal fluid into parasagittal dura along the superior sagittal sinus at areas nearby entry of cortical cerebral veins. The findings demonstrate that trans-arachnoid molecular passage does occur and suggest that parasagittal dura may serve as a bridging link between human brain and dural lymphatic vessels.

中文翻译：

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脑脊液示踪剂向人矢状硬脑膜外排。

从脑脊液到硬脑膜淋巴管分子运输的机制尚不清楚。这项研究利用磁共振成像和脑脊髓液示踪剂，可视化了体内硬脑膜淋巴管的清除途径。在18名怀疑各种类型的脑脊液疾病的受试者中，在鞘内给予造影剂加多布特罗（0.5 ml，1 mmol / ml），用作脑脊液示踪剂。在注射后3、6、24和48小时，T1序列追踪示踪剂的繁殖。示踪剂从皮层脑静脉入口附近的区域沿上矢状窦从脑脊液逸出到矢状旁硬脑膜。