Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.,Nature Communications

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Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
Nature Communications ( IF 14.7 ) Pub Date : 2020-01-17 , DOI: 10.1038/s41467-019-14159-1
Nicolai Franzmeier ₁ , Julia Neitzel ₁ , Anna Rubinski ₁ , Ruben Smith _{2,

3} , Olof Strandberg ₃ , Rik Ossenkoppele _{3,

4} , Oskar Hansson _{3,

5} , Michael Ewers ₁ ,

Affiliation

In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher fMRI-assessed connectivity between 400 regions of interest (ROIs) is associated with correlated tau-PET accumulation in corresponding ROIs. Third, we show that a model including baseline connectivity and tau-PET is associated with future tau-PET accumulation. Together, connectivity is associated with tau spread in AD, supporting the view of transneuronal tau propagation.

中文翻译：

功能性大脑结构与阿尔茨海默氏病中tau积累的速率有关。

在阿尔茨海默氏病（AD）中，tau病理与认知能力下降密切相关。临床前证据表明，tau以活动依赖的方式跨连接的神经元传播。支持这一点的横断面AD研究表明，tau沉积模式类似于功能性大脑网络。但是，尚不清楚更高的功能连接性是否与更高的tau积累速率相关。在这里，我们将静态fMRI与纵向tau-PET结合在两个独立的样本中，包括53个（ADNI）和41个（BioFINDER）淀粉样生物标志物定义的AD受试者以及28个（ADNI）与16个（BioFINDER）淀粉样阴性的健康对照。在这两个样本中，AD受试者的tau积累都比对照组快。其次，在公元在400个感兴趣区域（ROI）之间进行更高的fMRI评估的连通性与相应ROI中相关的tau-PET积累相关。第三，我们显示出一个包含基线连通性和tau-PET的模型与未来的tau-PET积累相关。在一起，连通性与tau在AD中的传播相关联，支持跨神经元tau传播的观点。

更新日期：2020-01-17

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