Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor.,Nature Communications

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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor.
Nature Communications ( IF 14.7 ) Pub Date : 2020-01-17 , DOI: 10.1038/s41467-019-14199-7
Dongdong Wang ₁ , Huihui Wu ₂ , Soo Zeng Fiona Phua ₁ , Guangbao Yang ₁ , Wei Qi Lim ₁ , Long Gu ₁ , Cheng Qian ₁ , Haibao Wang ₃ , Zhen Guo ₂ , Hongzhong Chen ₁ , Yanli Zhao _{1,

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Affiliation

Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The resulted OxgeMCC-r SAE possesses well-defined morphology, uniform size distribution and high loading capacity. When conducting the in situ O2 generation through the reaction between endogenous H2O2 and single-atom Ru species of OxgeMCC-r SAE, the hypoxia in tumor microenvironment is relieved. Our study demonstrates a promising self-assembled nanozyme with highly efficient single-atom catalytic sites for cancer treatment.

中文翻译：

自组装单原子纳米酶，用于增强光动力疗法治疗肿瘤。

实体瘤的缺氧损害了光动力疗法（PDT）的治疗效果，该疗法依赖于局部O2分子产生高度细胞毒性的单线态氧（1O2）。在这里，我们提出了一种安全且通用的自组装PDT纳米剂，即OxgeMCC-r单原子酶（SAE），由单原子钌作为固定在金属有机骨架Mn3 [Co（CN ）6] 2带有封装的二氢卟酚e6（Ce6），可作为过氧化氢酶样纳米酶来产生氧气。在存在生物相容性聚合物的情况下，有机连接基和金属离子的配位驱动自组装产生了纳米级网络，可自适应地封装Ce6。所得的OxgeMCC-r SAE具有明确的形态，均匀的尺寸分布和高负载能力。当通过内源性H2O2与OxgeMCC-r SAE的单原子Ru物种之间的反应进行原位O2生成时，肿瘤微环境中的低氧得以缓解。我们的研究证明了一种有前途的自组装纳米酶，具有高效的单原子催化位点，可用于癌症治疗。

更新日期：2020-01-17

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