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Background calcium induced by subthreshold depolarization modifies homosynaptic facilitation at a synapse in Aplysia.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-17 , DOI: 10.1038/s41598-019-57362-2
Bjoern Ch Ludwar 1, 2 , Klaudiusz R Weiss 1 , Elizabeth C Cropper 1
Affiliation  

Some synapses show two forms of short-term plasticity, homosynaptic facilitation, and a plasticity in which the efficacy of transmission is modified by subthreshold changes in the holding potential of the presynaptic neuron. In a previous study we demonstrated a further interactive effect. We showed that depolarizing changes in the presynaptic holding potential can increase the rate at which facilitation occurs. These experiments studied synaptic transmission between an Aplysia sensory neuron (B21) and its postsynaptic follower, the motor neuron (B8). We have also shown that subthreshold depolarizations of B21 produce widespread increases in its [Ca2+]i via activation of a nifedipine-sensitive current. To determine whether it is this change in 'background' calcium that modifies synaptic transmission we compared the facilitation observed at the B21-B8 synapse under control conditions to the facilitation observed in nifedipine. Nifedipine had a depressing effect. Other investigators studying facilitation have focused on Cares (i.e., the calcium that remains in a neuron after spiking). Our results indicate that facilitation can also be impacted by calcium channels opened before spiking begins.

中文翻译:

亚阈下去极化诱导的背景钙会改变海藻突触中的同态突触促进作用。

一些突触显示两种形式的短期可塑性,即同态突触促进作用和可塑性,其中通过阈值以下的突触前神经元保持力变化来修饰传递的功效。在先前的研究中,我们展示了进一步的交互作用。我们表明,去极化突触前保持潜力的变化可以增加促进发生的速度。这些实验研究了Aplysia感觉神经元(B21)和其突触后跟随者运动神经元(B8)之间的突触传递。我们还表明,通过激活硝苯地平敏感电流,B21的亚阈值去极化产生了其[Ca2 +] i的广泛增加。确定是否是“背景”中的此更改 改变突触传递的钙,我们将在对照条件下在B21-B8突触处观察到的促进作用与在硝苯地平中观察到的促进作用进行了比较。硝苯地平具有抑制作用。其他研究促进作用的研究者将注意力集中在Cares(即尖峰后保留在神经元中的钙)上。我们的结果表明,加标作用也可能受到加标开始前打开的钙通道的影响。
更新日期:2020-01-17
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