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Impact of succussion on pharmaceutical preparations analyzed by means of patterns from evaporated droplets.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-17 , DOI: 10.1038/s41598-019-57009-2 Maria Olga Kokornaczyk 1 , Sandra Würtenberger 2 , Stephan Baumgartner 1, 3, 4
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-17 , DOI: 10.1038/s41598-019-57009-2 Maria Olga Kokornaczyk 1 , Sandra Würtenberger 2 , Stephan Baumgartner 1, 3, 4
Affiliation
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The aim of the present study was to investigate if patterns obtained from evaporating droplets of pharmaceutical preparations reveal the impact of succussion on such medicinal products. For this purpose, five pharmaceutical preparations (Echinacea 10-2, Baptisia 10-3, Baptisia 10-4, Luffa 10-4, and Spongia 10-6) were prepared according to the European Pharmacopoeia guidelines for the production of homeopathic remedies, in three variants each: with varying numbers of succussion strokes (i) 100, (ii) 10 (succussed samples), and (iii) zero (gently mixed, unsuccussed sample). System stability was studied by means of systematic positive control experiments. Patterns were evaluated by means of computerized image analysis regarding grey level distribution, texture, and fractality. For all investigated pharmaceutical preparations, significant differences were found between the succussed and gently mixed samples; whereas, all three samples (prepared with 100, 10 and zero succussion strokes) could be significantly differentiated for Luffa 10-4 and Spongia 10-6 for one image evaluation parameter each. Control experiments showed a reasonable stability of the experimental set-up.
中文翻译：
悬浮液对药物制剂的影响通过蒸发液滴的图案进行分析。
本研究的目的是研究从药物制剂的蒸发液滴中获得的模式是否显示了悬液对此类药物的影响。为此，根据欧洲药典生产顺势疗法药物的指南，制备了五种药物制剂（紫锥花10-2，巴氏杆菌10-3，巴氏杆菌10-4，丝瓜10-4和海绵体10-6）。每个都有三个变体：（i）100个，（ii）10个（被采样的样本），和（iii）零个（轻轻混合，不被采样的样本）。通过系统的阳性对照实验研究了系统稳定性。通过关于灰度分布，纹理和分形的计算机图像分析来评估图案。对于所有调查的药物制剂，样品和轻度混合样品之间存在显着差异。而对于Luffa 10-4和Spongia 10-6，对于三个图像样本（分别具有100个，10个和0个震荡笔划），每个图像评估参数都有明显的区别。对照实验表明实验装置具有合理的稳定性。
更新日期：2020-01-17
中文翻译：
悬浮液对药物制剂的影响通过蒸发液滴的图案进行分析。
本研究的目的是研究从药物制剂的蒸发液滴中获得的模式是否显示了悬液对此类药物的影响。为此，根据欧洲药典生产顺势疗法药物的指南，制备了五种药物制剂（紫锥花10-2，巴氏杆菌10-3，巴氏杆菌10-4，丝瓜10-4和海绵体10-6）。每个都有三个变体：（i）100个，（ii）10个（被采样的样本），和（iii）零个（轻轻混合，不被采样的样本）。通过系统的阳性对照实验研究了系统稳定性。通过关于灰度分布，纹理和分形的计算机图像分析来评估图案。对于所有调查的药物制剂，样品和轻度混合样品之间存在显着差异。而对于Luffa 10-4和Spongia 10-6，对于三个图像样本（分别具有100个，10个和0个震荡笔划），每个图像评估参数都有明显的区别。对照实验表明实验装置具有合理的稳定性。
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