BACKGROUND Although use of cellular bone allografts (CBA) in orthopedic surgery has become increasingly common, little information is available regarding their short-term clinical performance. In these two case reports of two-stage hip arthroplasties, ViviGen Formable CBA (V-CBA) was used in stage one to fill voids left by previous metal implants. METHODS The two patients had distinctly different health profiles, but each of them had previous metal implants due to a hip fracture. In the otherwise healthy 49-year-old male patient, the total hip arthroplasty (THA) was performed 7 weeks after nail removal and V-CBA backfill. In the 64-year-old female patient with Type 1 diabetes and severe osteoporosis, stage 2 was performed after 12 weeks. At the time of THA for each patient, bone containing some V-CBA was removed to accommodate the hip implant. The explants were histologically analyzed for bone matrix, mineralization, and neovascularization. RESULTS Histological staining showed substantial new bone formation and neovascularization in both explants albeit at different levels of maturity. CONCLUSIONS Although limited, these results suggest that V-CBA may facilitate new bone formation in healthy as well as in metabolically challenged patients. LEVEL OF EVIDENCE V, case report.

中文翻译：

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在两阶段全髋关节置换中使用细胞骨同种异体移植后的临床结果和外植体组织学。

背景技术尽管在整形外科手术中使用细胞骨同种异体移植（CBA）已变得越来越普遍，但有关其短期临床表现的信息很少。在这两个阶段的髋关节置换术的两个病例报告中，在第一阶段使用了ViviGen Formable CBA（V-CBA）来填充以前的金属植入物留下的空隙。方法两名患者的健康状况截然不同，但由于髋部骨折，他们每个人都曾接受过金属植入。在原本健康的49岁男性患者中，在去除指甲和V-CBA回填后7周进行了全髋关节置换术（THA）。在患有1型糖尿病和严重骨质疏松症的64岁女性患者中，在12周后进行了2期治疗。在对每位患者进行THA手术时，将含有一些V-CBA的骨头切除以适应髋关节植入物。组织学分析外植体的骨基质，矿化和新血管形成。结果组织学染色显示两种外植体均存在大量新的骨形成和新血管形成，尽管处于不同的成熟水平。结论尽管有局限性，但这些结果表明V-CBA可以促进健康人群和代谢异常患者的新骨形成。证据级别V，案例报告。