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Comparison of sequential, delayed and simultaneous resection strategies for synchronous colorectal liver metastases.
BMC Surgery ( IF 1.9 ) Pub Date : 2020-01-17 , DOI: 10.1186/s12893-020-0681-7 Li-Jun Wang 1 , Hong-Wei Wang 1 , Ke-Min Jin 1 , Juan Li 1 , Bao-Cai Xing 1
BMC Surgery ( IF 1.9 ) Pub Date : 2020-01-17 , DOI: 10.1186/s12893-020-0681-7 Li-Jun Wang 1 , Hong-Wei Wang 1 , Ke-Min Jin 1 , Juan Li 1 , Bao-Cai Xing 1
Affiliation
BACKGROUND
The present study aimed to compare the perioperative safety and long-term survival of patients with synchronous colorectal liver metastases undergoing sequential resection (SeR), delayed resection (DeR) and simultaneous resection (SiR).
METHODS
From January 2007 to December 2016, data from patients undergoing surgery at Peking University Cancer Hospital for synchronous colorectal liver metastases were retrospectively collected. The above three different surgical strategies were compared.
RESULTS
A total of 233 cases were included, with 49 in the SeR group, 98 in the DeR group and 86 in the SiR group. The incidence of severe complications was 26.7% in the SiR group, higher than that in the DeR group (11.2%, P = 0.007) and the SeR group (16.3%, P = 0.166). The overall survival at 1 and 3 years in the SeR group (93.9 and 50.1%) was lower than that in the DeR group (94.9 and 64.8%, P = 0.019), but not significantly different from that in the SiR group (93.0 and 55.2%, P = 0.378). Recurrence-free survival at 1 and 3 years in the SeR group (22.4 and 18.4%) was lower than that in the DeR group (43.9 and 24.2%, P = 0.033) but not significantly different from that in the SiR group (31.4 and 19.6%, P = 0.275). Cox multivariate analysis indicated that T4, lymph node-positive primary tumour, liver metastases > 30 mm and SiR (compared with DeR) were correlated with poor prognosis.
CONCLUSION
Simultaneous resection has a relatively higher incidence of severe complications, and with a staged resection strategy, the prognosis of delayed resection was better than that of sequential resection.
更新日期：2020-01-17
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