BACKGROUND Most patients with multiple sclerosis (MS) suffer from bladder dysfunction during the course of the disease. This study was conducted to examine the prevalence of these complications among patients with MS. METHODS This cross-sectional study was performed on 602 patients with MS who referred to the neurology clinics of Kashani and Alzahra Hospitals affiliated to Isfahan University of Medical Sciences, Isfahan, Iran. Multistage random cluster sampling was performed and the informed consent form was signed by the subjects. Then, all the data were collected through interviews using the Lower Urinary Tract Symptom Score (LUTSS) developed in accordance with the definitions presented by the International Continence Society (ICS) and the International Prostate Symptom Score (I-PSS) and DASS-21 questionnaire. The data were analyzed using descriptive and inferential statistical tests in SPSS. RESULTS The prevalence rate of lower urinary tract symptoms (LUTS) was 87.6% among all the subjects, with a similar rate among women (88.0%) and men (86.0%). There was a significant difference between men and women in terms of the prevalence of stress urinary incontinence (SUI), intermittent urine flow, hesitancy, straining, and dribbling (P <  0.050). There was no significant difference between women and men in terms of the prevalence of other symptoms (P > 0.050). A significant difference was observed in the degree of LUTS with age, marital status, marriage duration, education, illness duration, clinical course, disability, anxiety, depression, and stress (P<  0.05). Moreover, logistic regression analysis revealed that there was a higher probability of a urinary problems among patients with MS and a high EDSS score [0.67 (0.507-0.903), P = 0.008]. CONCLUSIONS A high prevalence of LUTS was found among patients with MS. There was a higher probability of a urinary tract problem among patients with MS and a high EDSS score. Therefore, it is recommended that the health system take the necessary measures regarding timely detection and treatment of LUTS among these patients in order to prevent secondary outcomes and improve the quality of life (QOL) of patients with MS.

中文翻译：

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根据多发性硬化症患者的个人和临床参数，下尿路症状的患病率。

背景技术大多数患有多发性硬化症（MS）的患者在疾病过程中患有膀胱功能障碍。这项研究旨在检查MS患者中这些并发症的患病率。方法本横断面研究是针对602例MS患者进行的，这些患者转诊至伊朗伊斯法罕伊斯法罕医学大学附属的Kashani和Alzahra医院的神经内科诊所。进行多阶段随机整群抽样，受试者签署知情同意书。然后，使用根据国际尿失禁协会（ICS）提出的定义以及国际前列腺症状评分（I-PSS）和DASS-21调查表制定的下尿路症状评分（LUTSS），通过访谈收集所有数据。 。使用描述性和推断性统计检验在SPSS中对数据进行了分析。结果在所有受试者中，下尿路症状（LUTS）的患病率为87.6％，女性（88.0％）和男性（86.0％）的患病率相似。在压力性尿失禁（SUI），间歇性尿流，犹豫，紧张和运球方面，男女之间存在显着差异（P <0.050）。就其他症状的患病率而言，男女之间无显着差异（P> 0.050）。LUTS的程度随年龄，婚姻状况，婚姻持续时间，受教育程度，疾病持续时间，临床病程，残疾，焦虑，抑郁和压力而有显着差异（P <0.05）。此外，Logistic回归分析显示，MS患者和EDSS评分较高的患者出现尿液问题的可能性更高[0.67（0.507-0.903），P = 0.008]。结论在MS患者中发现LUTS的患病率很高。MS和EDSS评分高的MS患者发生尿路问题的可能性更高。因此，建议卫生系统采取必要措施及时检测和治疗这些患者中的LUTS，以防止继发性后果并改善MS患者的生活质量（QOL）。MS和EDSS评分高的MS患者发生尿路问题的可能性更高。因此，建议卫生系统采取必要措施及时检测和治疗这些患者中的LUTS，以防止继发性后果并改善MS患者的生活质量（QOL）。MS和EDSS评分高的MS患者发生尿路问题的可能性更高。因此，建议卫生系统采取必要措施及时检测和治疗这些患者中的LUTS，以防止继发性后果并改善MS患者的生活质量（QOL）。