BACKGROUND Genetic predisposition plays an important role in the development of alcoholic pancreatitis (AP), with previous studies suggesting that genetics variants in certain genes, such asCYP2E1 and CTRC, partially explain individual susceptibility to this disease. Therefore, the aim of this work was to conduct a systematic review and meta-analysis of existing studies that analyzed how polymorphisms within CYP2E1 and CTRC genes influence the risk of AP. MATERIAL AND METHODS We performed a systematic review of studies that analyzed the genotype distribution of CYP2E1 and CTRC allelic variants among patients with AP and a group of controls. A meta-analysis was conducted using a random effects model. Odds ratios (ORs) and their confidence intervals (CIs) were calculated. RESULTS The T allele of theCTRC 180 C > T variant was significantly more prevalent among patients with AP compared to all controls (OR = 1.79, 95% CI = 1.43-2.24; P < 0.00001) and healthy subjects (OR = 1.84, 95% CI = 1.46-2.31; P < 0.00001). The Trp variant of CTRC Arg254Trp polymorphism was also more prevalent in patients with AP; however, these results were not significant after excluding one study. We found no clear evidence that CYP2E1-DraI or of CYP2E1-RsaI/PstI polymorphisms modulate the risk of developing AP. CONCLUSIONS Our meta-analysis supports that the T allele ofCTRC 180C > T polymorphisms modulates the risk of alcoholic pancreatitis. No clear evidence was found for the remaining SNPs being associated with this disease.

中文翻译：

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CYP2E1和CTRC基因的遗传变异与酒精性胰腺炎的易感性之间的关联：系统评价和荟萃分析。

背景技术遗传易感性在酒精性胰腺炎（AP）的发展中起着重要作用，先前的研究表明某些基因的遗传变异，例如CYP2E1和CTRC，部分地解释了个体对该病的易感性。因此，这项工作的目的是对现有研究进行系统的回顾和荟萃分析，分析CYP2E1和CTRC基因内的多态性如何影响AP的风险。材料与方法我们对研究进行了系统的综述，分析了CYP2E1和CTRC等位基因变体在AP患者和一组对照组中的基因型分布。使用随机效应模型进行荟萃分析。计算赔率（OR）及其置信区间（CI）。结果CTRC 180 C的T等位基因> 与所有对照组（OR = 1.79，95％CI = 1.43-2.24; P <0.00001）和健康受试者（OR = 1.84，95％CI = 1.46-2.31; P <0.00001）相比，AP患者中的T变异更为普遍）。CTRC Arg254Trp多态性的Trp变异在AP患者中也更为普遍。但是，排除一项研究后，这些结果并不显着。我们没有发现明确的证据表明CYP2E1-DraI或CYP2E1-RsaI / PstI多态性可调节发生AP的风险。结论我们的荟萃分析支持CTRC 180C的T等位基因> T多态性调节酒精性胰腺炎的风险。尚无明确证据表明其余SNP与该疾病有关。95％CI = 1.46-2.31; P <0.00001）。CTRC Arg254Trp多态性的Trp变异在AP患者中也更为普遍。但是，排除一项研究后，这些结果并不显着。我们没有发现明确的证据表明CYP2E1-DraI或CYP2E1-RsaI / PstI多态性可调节发生AP的风险。结论我们的荟萃分析支持CTRC 180C的T等位基因> T多态性调节酒精性胰腺炎的风险。尚无明确证据表明其余SNP与该疾病有关。95％CI = 1.46-2.31; P <0.00001）。CTRC Arg254Trp多态性的Trp变异在AP患者中也更为普遍。但是，排除一项研究后，这些结果并不显着。我们没有发现明确的证据表明CYP2E1-DraI或CYP2E1-RsaI / PstI多态性可调节发生AP的风险。结论我们的荟萃分析支持CTRC 180C的T等位基因> T多态性调节酒精性胰腺炎的风险。尚无明确证据表明其余SNP与该疾病有关。结论我们的荟萃分析支持CTRC 180C的T等位基因> T多态性调节酒精性胰腺炎的风险。尚无明确证据表明其余SNP与该疾病有关。结论我们的荟萃分析支持CTRC 180C的T等位基因> T多态性调节酒精性胰腺炎的风险。尚无明确证据表明其余SNP与该疾病有关。