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Fasting C-peptide is a significant indicator of nonalcoholic fatty liver disease in obese children.
Diabetes Research and Clinical Practice ( IF 6.1 ) Pub Date : 2020-01-17 , DOI: 10.1016/j.diabres.2020.108027
Xiucui Han 1 , Pengfei Xu 2 , Jianming Zhou 1 , Yongxia Liu 3 , Hui Xu 1
Affiliation  

AIMS Whether fasting C-peptide can be a potential indicator for nonalcoholic fatty liver disease (NAFLD) in obese children is unknown. This study aimed to assess whether fasting C-peptide represented a risk factor for NAFLD. METHODS A total of 520 obese children (376 male, 144 female) aged 3.4-17.1 years were divided into two groups, obese with NAFLD and non-NAFLD, according to hepatic ultrasound results. Fasting plasma glucose, fasting C-peptide, hemoglobin A1c, renal function, liver function, blood lipid, fasting insulin and blood routine indices were measured. Insulin resistance by homoeostasis model (HOMA-IR) was calculated. RESULTS Compared with the non-NAFLD group, the obese children with NAFLD had higher fasting C-peptide, fasting insulin and HOMA-IR (P < 0.001). Stepwise multiple logistic regression models showed that fasting C-peptide (odds ratio: OR = 2.367) was independent indicator of the presence of NAFLD in obese children as well as white blood cell (OR = 1.113), albumin (OR = 1.124), alanine aminotransferase (OR = 1.030), triglycerides (OR = 1.335), and waist circumference (OR = 1.047). Furthermore, after adjustment for confounding variables, the prevalence of NAFLD in obese children was significantly higher according to increased serum fasting C-peptide levels. The adjusted OR for NAFLD according to fasting C-peptide tertiles were 1.00 (as references), 1.896(1.045-3.436), and 4.169(1.822-9.537). CONCLUSION Our data suggested that obese children with high level of fasting C-peptide had an increased risk for developing NAFLD.

中文翻译:

空腹C肽是肥胖儿童非酒精性脂肪肝的重要指标。

目的禁食C肽是否可以成为肥胖儿童非酒精性脂肪肝疾病(NAFLD)的潜在指标。这项研究旨在评估空腹C肽是否代表NAFLD的危险因素。方法根据肝超声检查结果,将520例3.4-17.1岁的肥胖儿童(376名男性,144名女性)分为NAFLD和非NAFLD肥胖两组。测定空腹血糖,空腹C肽,血红蛋白A1c,肾功能,肝功能,血脂,空腹胰岛素和血液常规指标。通过均流模型(HOMA-IR)计算胰岛素抵抗。结果与非NAFLD组相比,肥胖的NAFLD患儿的空腹C肽,空腹胰岛素和HOMA-IR较高(P <0.001)。逐步多元logistic回归模型显示,空腹C肽(优势比:OR = 2.367)是肥胖儿童以及白细胞(OR = 1.113),白蛋白(OR = 1.124),丙氨酸中NAFLD的独立指标。氨基转移酶(OR = 1.030),甘油三酸酯(OR = 1.335)和腰围(OR = 1.047)。此外,在调整了混杂变量之后,肥胖儿童的NAFLD患病率随着血清禁食C肽水平的升高而明显升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00(作为参考),1.896(1.045-3.436)和4.169(1.822-9.537)。结论我们的数据表明,空腹C肽水平高的肥胖儿童患NAFLD的风险增加。367)是肥胖儿童以及白细胞(OR = 1.113),白蛋白(OR = 1.124),丙氨酸转氨酶(OR = 1.030),甘油三酸酯(OR = 1.335)和腰围存在的独立指标(或= 1.047)。此外,在调整了混杂变量后,肥胖儿童的NAFLD患病率随着血清空腹C肽水平的升高而显着升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00(作为参考),1.896(1.045-3.436)和4.169(1.822-9.537)。结论我们的数据表明,空腹C肽水平高的肥胖儿童患NAFLD的风险增加。367)是肥胖儿童以及白细胞(OR = 1.113),白蛋白(OR = 1.124),丙氨酸转氨酶(OR = 1.030),甘油三酸酯(OR = 1.335)和腰围存在的独立指标(或= 1.047)。此外,在调整了混杂变量后,肥胖儿童的NAFLD患病率随着血清空腹C肽水平的升高而显着升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00(作为参考),1.896(1.045-3.436)和4.169(1.822-9.537)。结论我们的数据表明,空腹C肽水平高的肥胖儿童患NAFLD的风险增加。和腰围(OR = 1.047)。此外,在调整了混杂变量之后,肥胖儿童的NAFLD患病率随着血清禁食C肽水平的升高而明显升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00(作为参考),1.896(1.045-3.436)和4.169(1.822-9.537)。结论我们的数据表明,空腹C肽水平高的肥胖儿童患NAFLD的风险增加。和腰围(OR = 1.047)。此外,在调整了混杂变量后,肥胖儿童的NAFLD患病率随着血清空腹C肽水平的升高而显着升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00(作为参考),1.896(1.045-3.436)和4.169(1.822-9.537)。结论我们的数据表明,空腹C肽水平高的肥胖儿童患NAFLD的风险增加。
更新日期:2020-01-17
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