AIMS Whether fasting C-peptide can be a potential indicator for nonalcoholic fatty liver disease (NAFLD) in obese children is unknown. This study aimed to assess whether fasting C-peptide represented a risk factor for NAFLD. METHODS A total of 520 obese children (376 male, 144 female) aged 3.4-17.1 years were divided into two groups, obese with NAFLD and non-NAFLD, according to hepatic ultrasound results. Fasting plasma glucose, fasting C-peptide, hemoglobin A1c, renal function, liver function, blood lipid, fasting insulin and blood routine indices were measured. Insulin resistance by homoeostasis model (HOMA-IR) was calculated. RESULTS Compared with the non-NAFLD group, the obese children with NAFLD had higher fasting C-peptide, fasting insulin and HOMA-IR (P < 0.001). Stepwise multiple logistic regression models showed that fasting C-peptide (odds ratio: OR = 2.367) was independent indicator of the presence of NAFLD in obese children as well as white blood cell (OR = 1.113), albumin (OR = 1.124), alanine aminotransferase (OR = 1.030), triglycerides (OR = 1.335), and waist circumference (OR = 1.047). Furthermore, after adjustment for confounding variables, the prevalence of NAFLD in obese children was significantly higher according to increased serum fasting C-peptide levels. The adjusted OR for NAFLD according to fasting C-peptide tertiles were 1.00 (as references), 1.896(1.045-3.436), and 4.169(1.822-9.537). CONCLUSION Our data suggested that obese children with high level of fasting C-peptide had an increased risk for developing NAFLD.

中文翻译：

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空腹C肽是肥胖儿童非酒精性脂肪肝的重要指标。

目的禁食C肽是否可以成为肥胖儿童非酒精性脂肪肝疾病（NAFLD）的潜在指标。这项研究旨在评估空腹C肽是否代表NAFLD的危险因素。方法根据肝超声检查结果，将520例3.4-17.1岁的肥胖儿童（376名男性，144名女性）分为NAFLD和非NAFLD肥胖两组。测定空腹血糖，空腹C肽，血红蛋白A1c，肾功能，肝功能，血脂，空腹胰岛素和血液常规指标。通过均流模型（HOMA-IR）计算胰岛素抵抗。结果与非NAFLD组相比，肥胖的NAFLD患儿的空腹C肽，空腹胰岛素和HOMA-IR较高（P <0.001）。逐步多元logistic回归模型显示，空腹C肽（优势比：OR = 2.367）是肥胖儿童以及白细胞（OR = 1.113），白蛋白（OR = 1.124），丙氨酸中NAFLD的独立指标。氨基转移酶（OR = 1.030），甘油三酸酯（OR = 1.335）和腰围（OR = 1.047）。此外，在调整了混杂变量之后，肥胖儿童的NAFLD患病率随着血清禁食C肽水平的升高而明显升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00（作为参考），1.896（1.045-3.436）和4.169（1.822-9.537）。结论我们的数据表明，空腹C肽水平高的肥胖儿童患NAFLD的风险增加。367）是肥胖儿童以及白细胞（OR = 1.113），白蛋白（OR = 1.124），丙氨酸转氨酶（OR = 1.030），甘油三酸酯（OR = 1.335）和腰围存在的独立指标（或= 1.047）。此外，在调整了混杂变量后，肥胖儿童的NAFLD患病率随着血清空腹C肽水平的升高而显着升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00（作为参考），1.896（1.045-3.436）和4.169（1.822-9.537）。结论我们的数据表明，空腹C肽水平高的肥胖儿童患NAFLD的风险增加。367）是肥胖儿童以及白细胞（OR = 1.113），白蛋白（OR = 1.124），丙氨酸转氨酶（OR = 1.030），甘油三酸酯（OR = 1.335）和腰围存在的独立指标（或= 1.047）。此外，在调整了混杂变量后，肥胖儿童的NAFLD患病率随着血清空腹C肽水平的升高而显着升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00（作为参考），1.896（1.045-3.436）和4.169（1.822-9.537）。结论我们的数据表明，空腹C肽水平高的肥胖儿童患NAFLD的风险增加。和腰围（OR = 1.047）。此外，在调整了混杂变量之后，肥胖儿童的NAFLD患病率随着血清禁食C肽水平的升高而明显升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00（作为参考），1.896（1.045-3.436）和4.169（1.822-9.537）。结论我们的数据表明，空腹C肽水平高的肥胖儿童患NAFLD的风险增加。和腰围（OR = 1.047）。此外，在调整了混杂变量后，肥胖儿童的NAFLD患病率随着血清空腹C肽水平的升高而显着升高。根据空腹C肽三分位数对NAFLD的调整后OR为1.00（作为参考），1.896（1.045-3.436）和4.169（1.822-9.537）。结论我们的数据表明，空腹C肽水平高的肥胖儿童患NAFLD的风险增加。