This study was aimed at investigating the effect of grewia polysaccharides on the mechanical and release properties of tablet matrices containing binary mixtures of the polysaccharide with psyllium. Two grades of grewia polysaccharides (GG and GDS) were extracted and binary mixtures of the polysaccharides with psyllium were formulated into tablet matrices containing theophylline as the model drug. The true, bulk and tapped densities, Carr's compressibility index of the powders and binary composites were determined before tablet compression. Tablet properties (hardness, porosity, and drug release from the matrices) were investigated. The dissolution test was carried out in 0.1 M HCl (pH 1.2) and phosphate buffer (pH 6.8). The results show that GG and GDS produced tablets with good mechanical strength (108.33 N and 95.70 N, respectively) while psyllium produced softer tablets (7.13 N). The combination of psyllium and grewia polysaccharides in the matrices resulted in a significant increase in the mechanical strength of the matrices when compared to matrices containing psyllium alone as the matrix former. The results also showed that GG and GDS reduced the dissolution rate and effectively eliminated the burst release of theophylline from the psyllium matrices at both pHs. The matrices of GG or GDS and the binary mixtures conform to non-Fickian anomalous diffusion with n > 0.45. When overcoming the burst release of drug from matrices such as psyllium, grewia polysaccharides may provide an effective reduction and a more sustained drug release from such matrices.

中文翻译：

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茶碱从含有车前子粉和长果多糖的基质片剂中的机械和释放行为。

这项研究旨在调查aimed藜多糖对含有多糖与车前草二元混合物的片剂的机械性能和释放性能的影响。提取两种等级的生长多糖（GG和GDS），并将多糖与车前子的二元混合物配制为以茶碱为模型药物的片剂基质。在压片之前，测定粉末和二元复合材料的真实密度，堆积密度和振实密度，卡尔压缩系数。研究了片剂的性质（硬度，孔隙率和从基质中释放的药物）。溶出度试验在0.1 M HCl（pH 1.2）和磷酸盐缓冲液（pH 6.8）中进行。结果表明，GG和GDS生产的片剂具有良好的机械强度（108.33 N和95.70 N，车前子产生较软的片剂（7.13 N）。与仅含有车前草作为基质形成剂的基质相比，基质中的车前子和生长多糖的组合导致基质的机械强度显着提高。结果还表明，GG和GDS降低了溶解速率并有效消除了茶碱在两种pH下茶碱的突释。GG或GDS的矩阵以及二元混合物符合n = 0.45的非Fickian异常扩散。当克服药物从诸如车前草的基质中的爆发释放时，grew藜多糖可提供有效的减少并从此类基质中更持久地释放药物。与仅含有车前草作为基质形成剂的基质相比，基质中的车前子和生长多糖的组合导致基质的机械强度显着提高。结果还表明，GG和GDS降低了溶解速率并有效消除了茶碱在两种pH下茶碱的突释。GG或GDS的矩阵以及二元混合物符合n = 0.45的非Fickian异常扩散。当克服药物从诸如车前草的基质中的爆发释放时，grew藜多糖可提供有效的减少并从此类基质中更持久地释放药物。与仅含有车前草作为基质形成剂的基质相比，基质中的车前子和生长多糖的组合导致基质的机械强度显着提高。结果还表明，GG和GDS降低了溶解速率并有效消除了茶碱在两种pH下茶碱的突释。GG或GDS的矩阵以及二元混合物符合n = 0.45的非Fickian异常扩散。当克服药物从诸如车前草的基质中的爆发释放时，grew藜多糖可提供有效的减少并从此类基质中更持久地释放药物。结果还表明，GG和GDS降低了溶解速率并有效消除了茶碱在两种pH下茶碱的突释。GG或GDS的矩阵以及二元混合物符合n = 0.45的非Fickian异常扩散。当克服药物从诸如车前草的基质中的爆发释放时，grew藜多糖可提供有效的减少并从此类基质中更持久地释放药物。结果还表明，GG和GDS降低了溶解速率并有效消除了茶碱在两种pH下茶碱的突释。GG或GDS的矩阵以及二元混合物符合n = 0.45的非Fickian异常扩散。当克服药物从诸如车前草的基质中的爆发释放时，grew藜多糖可提供有效的减少并从此类基质中更持久地释放药物。