Irradiation of cancer cells by non-ionizing millimeter waves (MMW) causes increased cell mortality. We examined if MMW have toxic effects on healthy mice. To that end, the skin of healthy C57BL/6 mice was irradiated locally at the right flank with 101 GHz MMW in a pulsed (5-10 µs) regime using a free electron laser. Irradiation was performed in a dose-dependent manner, with 20-50 pulses and a power range of 0.5-1.5 kW. Physical, physiological, and pathological parameters as well as behavior were examined before and after irradiation. Our results showed that all parameters were within normal range for all experimental mice groups and for the control group. No significant changes were noted in the physical, physiological, or behavioral status of the mice following irradiation as compared with the control group. In addition, no significant changes were found in locomotor, exploratory behavior, or anxiety of the irradiated mice and no pathological changes were noted following the hematological and biochemical blood analysis. Our results indicate that irradiation of healthy mice with MMW does not cause any general toxic effects. Bioelectromagnetics. © 2020 Bioelectromagnetics Society.

中文翻译：

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大功率短脉冲101 GHz毫米波对健康小鼠没有毒性作用。

通过非电离毫米波（MMW）照射癌细胞会导致细胞死亡率增加。我们检查了MMW是否对健康小鼠具有毒性作用。为此，使用自由电子激光以脉冲（5-10 µs）的方式，以101 GHz MMW在右侧腹局部照射健康的C57BL / 6小鼠的皮肤。以20-50个脉冲和0.5-1.5 kW的功率范围以剂量依赖的方式进行辐照。在照射前后检查身体，生理和病理参数以及行为。我们的结果表明，所有实验小鼠组和对照组的所有参数均在正常范围内。与对照组相比，辐照后小鼠的生理，生理或行为状态未见明显变化。此外，经血液和生化血液分析后，未发现受辐照的小鼠的运动，探索行为或焦虑发生明显变化，也未发现病理变化。我们的结果表明，用MMW照射健康小鼠不会引起任何一般的毒性作用。生物电磁学。©2020生物电磁学会。