Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2).,ChemBioChem

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Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2).
ChemBioChem ( IF 2.6 ) Pub Date : 2020-01-17 , DOI: 10.1002/cbic.201900776
Kourosh Honarmand Ebrahimi ₁ , Jack S Rowbotham ₁ , James McCullagh ₁ , William S James ₂

Affiliation

Fungal to antiviral : A new fungal radical‐SAM enzyme homologue of the human antiviral enzyme can catalyse the transformation of a range of natural or unnatural nucleotides to their analogues through a proton‐coupled electron transfer mechanism. The enzyme offers new biocatalytic routes for synthesis of 3′‐deoxy nucleotides/nucleosides as an important group of antiviral, antibacterial, or anticancer drugs.

中文翻译：

抗病毒酶 Viperin (RSAD2) 的混杂自由基-SAM 酶同系物导致二醇脱水的机制。

真菌抗病毒：人类抗病毒酶的新型真菌自由基-SAM酶同系物可以通过质子耦合电子转移机制催化一系列天然或非天然核苷酸转化为其类似物。该酶为 3′-脱氧核苷酸/核苷的合成提供了新的生物催化途径，作为一组重要的抗病毒、抗菌或抗癌药物。

更新日期：2020-01-17

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