Effects of the trifluoromethoxy substituent on physico-chemical properties of compounds, such as kinetic solubility, lipophilicity and microsomal clearance, was studied in a series of aliphatic derivatives. It was found that kinetic solubility of the CF₃O-containing compounds was comparable to that of analogs, i.e. compounds bearing CH₃O and CF₃ moieties. The CF₃O-substituted compounds had higher lipophilicity as compared to methoxy analogues, and nearly the same like CF₃-bearing compounds. Microsomal stability studies indicated that the trifluoromethoxy group typically decreased metabolic stability of the corresponding derivatives as compared to either CH₃O- or CF₃-substituted counterparts, except for N-alkoxy(sulfon)amide series.

在一系列脂族衍生物中研究了三氟甲氧基取代基对化合物理化性质的影响，如动力学溶解度，亲脂性和微粒体清除率。发现含CF ₃ O的化合物的动力学溶解度与类似物，即具有CH ₃ O和CF ₃部分的化合物的动力学溶解度相当。与甲氧基类似物相比，CF ₃ O-取代的化合物具有更高的亲脂性，并且与带有CF _3的化合物几乎相同。微粒体稳定性研究表明，与任一CH ₃相比，三氟甲氧基通常会降低相应衍生物的代谢稳定性O-或CF ₃取代的对应物，但N-烷氧基（磺）酰胺系列除外。