Gastric cancer represents a deadly malignancy worldwide, yet current therapeutic regimens remain ineffective. Nanoparticle (NP) -based solutions could allow the design of novel therapeutic methods to eliminate this fatal disease. NPs typically carry out a significant role in multifunctional, multimodal imaging, and drug delivery carriers. In the recent decade, they have emerged as candidate approaches for the design of novel treatment strategies. Tumor nanotherapeutics characteristically possess various distinct advantages compared to conventional anti-cancer medications, which suffer from nonspecific bio-distribution, low solubility, and poor bioavailability. In this review, we will discuss the application of NPs in diagnosis and controlled drug delivery in gastric cancer (GC). We will focus on various NPs-based strategies employed against GC.

中文翻译：

---

纳米颗粒指导胃癌中的药物输送和成像。

胃癌在世界范围内是一种致命的恶性肿瘤，但目前的治疗方案仍然无效。基于纳米粒子 (NP) 的解决方案可以设计出新的治疗方法来消除这种致命疾病。NPs 通常在多功能、多模式成像和药物输送载体中发挥重要作用。在最近十年中，它们已成为设计新治疗策略的候选方法。与传统的抗癌药物相比，肿瘤纳米治疗具有各种明显的优势，传统的抗癌药物具有非特异性生物分布、低溶解度和较差的生物利用度。在这篇综述中，我们将讨论 NPs 在胃癌 (GC) 诊断和控制药物递送中的应用。我们将专注于针对 GC 采用的各种基于 NP 的策略。