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Vagal sensory neurons drive mucous cell metaplasia.
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.jaci.2020.01.003
Sébastien Talbot 1 , Benjamin Doyle 2 , Junwei Huang 2 , Jo-Chiao Wang 3 , Maryam Ahmadi 3 , David P Roberson 2 , Ajay Yekkirala 2 , Simmie L Foster 2 , Liam E Browne 4 , Bruce P Bean 5 , Bruce D Levy 6 , Clifford J Woolf 2
Affiliation  

Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.



中文翻译:

迷走神经感觉神经元驱动粘液细胞化生。

气道感觉神经元产生的 P 物质会增加过敏引起的杯状细胞增生和 Muc5AC 的过度分泌,电沉默这些过度反应的神经元可减少肺 2 型过敏性炎症反应的这些成分。

更新日期:2020-01-17
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