Some new kinds of antibiotics-free antibacterial agents are required to deal with bacterial infections due to the occurrence of drug-resistance. In this work, Cu-based metal-organic framework (HKUST-1) embedded with CuS NPs were fabricated via a simple in-situ sulfuration process. The synthesized MOFs exhibited an highly effective disinfection efficacy of 99.70 % and 99.80 % against Staphylococcus aureus and Escherichia coli within 20 min irradiation of near-infrared (NIR) light, respectively, which was ascribed to the cooperative effects of photodynamic and photothermal effects of the composites. A certain amount of Cu2+ ions of the MOFs were reacted to form CuS NPs, which endowed this composite with outstanding photocatalytic and photothermal performance during NIR light irradiation. Moreover, HKUST-1 that composed of low toxic organic ligand 1,3,5-benzenetricarboxylic acid (H3BTC) coordinating copper ions could be a controllable carrier that imposed certain constraint on the NPs. Hence, these CuS@HKUST-1 would be a promising bioplatform for rapid bacteria-killing.

中文翻译：

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铜基金属有机骨架的原位硫化，用于快速近红外光灭菌。

由于耐药性的发生，需要一些新型的无抗生素抗菌剂来应对细菌感染。在这项工作中，通过简单的原位硫化工艺制备了嵌入CuS NP的Cu基金属有机骨架（HKUST-1）。合成的MOFs在近红外（NIR）光照射下20分钟内分别对金黄色葡萄球菌和大肠埃希菌表现出99.70％和99.80％的高效消毒效果，这归因于该酶的光动力作用和光热作用的协同作用复合材料。MOF的一定数量的Cu2 +离子反应形成CuS NP，这使该复合材料在NIR光照射期间具有出色的光催化和光热性能。此外，由低毒有机配体1组成的HKUST-1 3,5-苯三甲酸（H3BTC）配位铜离子可能是可控的载体，对NPs施加了一定的限制。因此，这些CuS @ HKUST-1将是一种有希望的快速杀灭细菌的生物平台。