Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat diet increases the risk of OA for two generations of offspring, raising questions about disease mechanisms and future treatment strategies.

中文翻译：

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父母肥胖如何促进几代人的OA？

肥胖会通过复杂的，尚未完全了解的生物力学，代谢和炎症因素来促进骨关节炎（OA）。小鼠的新数据通过显示高脂饮食增加了两代后代的OA风险，从而增加了这种复杂性，引发了有关疾病机制和未来治疗策略的问题。