The aim of this study was to develop a novel system for the co-delivery of resveratrol and coenzyme Q10 (CoQ10). It was achieved with a combination of resveratrol-loaded composite nanoparticles and CoQ10-loaded Pickering emulsions. Different levels of resveratrol (0.05-0.30%, w/v) were entrapped into composite nanoparticles by the method of emulsification-evaporation. The size of composite nanoparticles was around 300-600 nm, and the maximum loading capacity of resveratrol was up to 13.88% (w/w). Hydrogen bonds, hydrophobic effects, and electrostatic attraction participated in the self-assembly of composite nanoparticles. The stability of CoQ10 Pickering emulsions was monitored under simulated environmental stresses (pH, ionic strength, UV radiation, and heat) and accelerated storage conditions. The physical stability of Pickering emulsions was dependent on the particle compositions, and the CoQ10 entrapped was also protected by the resveratrol-loaded nanoparticles. The morphology of Pickering emulsions was observed with the aid of optical microscopy, confocal laser scanning microscopy, and cryo-scanning electronic microscopy. The nutraceutical Pickering emulsions were designed for the co-delivery of resveratrol and CoQ10, which has the potential to be a novel vehicle for bioactive ingredients.

中文翻译：

---

负载白藜芦醇的复合纳米颗粒稳定的辅酶Q10 Pickering乳液的制备，理化稳定性和微观结构。

这项研究的目的是开发白藜芦醇和辅酶Q10（CoQ10）共同输送的新型系统。负载白藜芦醇的复合纳米颗粒和负载辅酶Q10的Pickering乳液共同实现了这一目标。通过乳化-蒸发的方法将不同含量的白藜芦醇（0.05-0.30％，w​​ / v）截留在复合纳米颗粒中。复合纳米粒子的尺寸约为300-600 nm，白藜芦醇的最大负载量高达13.88％（w / w）。氢键，疏水作用和静电吸引参与了复合纳米颗粒的自组装。在模拟的环境压力（pH，离子强度，UV辐射和热量）和加速存储条件下，监测CoQ10 Pickering乳液的稳定性。Pickering乳液的物理稳定性取决于颗粒的组成，并且被白藜芦醇负载的纳米颗粒也保护了被困的CoQ10。借助光学显微镜，共聚焦激光扫描显微镜和冷冻扫描电子显微镜观察Pickering乳液的形态。营养品Pickering乳液是为白藜芦醇和CoQ10的共同输送而设计的，它有可能成为生物活性成分的新型载体。