Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The arms race between bacteria and their phage foes
Nature ( IF 50.5 ) Pub Date : 2020-01-15 , DOI: 10.1038/s41586-019-1894-8 Hannah G Hampton 1 , Bridget N J Watson 1, 2 , Peter C Fineran 1
Nature ( IF 50.5 ) Pub Date : 2020-01-15 , DOI: 10.1038/s41586-019-1894-8 Hannah G Hampton 1 , Bridget N J Watson 1, 2 , Peter C Fineran 1
Affiliation
|
Bacteria are under immense evolutionary pressure from their viral invaders—bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and adaptive, to cope with this pressure. The discovery and exploitation of CRISPR–Cas systems have stimulated a resurgence in the identification and characterization of anti-phage mechanisms. Bacteriophages use an extensive battery of counter-defence strategies to co-exist in the presence of these diverse phage defence mechanisms. Understanding the dynamics of the interactions between these microorganisms has implications for phage-based therapies, microbial ecology and evolution, and the development of new biotechnological tools. Here we review the spectrum of anti-phage systems and highlight their evasion by bacteriophages. Understanding the dynamics between bacteria and bacteriophages could enable the development of phage-based therapies and biotechnological tools and provide insights into the ecology and evolution of these microorganisms.
中文翻译：
细菌与其噬菌体敌人之间的军备竞赛
细菌承受着来自病毒入侵者——噬菌体的巨大进化压力。细菌已经进化出多种免疫机制，包括先天的和适应性的，以应对这种压力。CRISPR-Cas 系统的发现和利用刺激了抗噬菌体机制的鉴定和表征的复兴。噬菌体使用大量的反防御策略在这些不同的噬菌体防御机制存在的情况下共存。了解这些微生物之间相互作用的动力学对基于噬菌体的疗法、微生物生态学和进化以及新生物技术工具的开发具有重要意义。在这里，我们回顾了抗噬菌体系统的范围，并强调了噬菌体对它们的逃避。
更新日期：2020-01-15
中文翻译：
细菌与其噬菌体敌人之间的军备竞赛
细菌承受着来自病毒入侵者——噬菌体的巨大进化压力。细菌已经进化出多种免疫机制，包括先天的和适应性的，以应对这种压力。CRISPR-Cas 系统的发现和利用刺激了抗噬菌体机制的鉴定和表征的复兴。噬菌体使用大量的反防御策略在这些不同的噬菌体防御机制存在的情况下共存。了解这些微生物之间相互作用的动力学对基于噬菌体的疗法、微生物生态学和进化以及新生物技术工具的开发具有重要意义。在这里，我们回顾了抗噬菌体系统的范围，并强调了噬菌体对它们的逃避。
京公网安备 11010802027423号