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Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age.
PLOS ONE ( IF 2.9 ) Pub Date : 2020-01-15 , DOI: 10.1371/journal.pone.0227696 Sergio Cordovilla-Guardia 1, 2 , Tania Bautista Molina 3 , Cristina Franco-Antonio 1, 2 , Esperanza Santano-Mogena 1, 2 , Raquel Vilar-López 4, 5
PLOS ONE ( IF 2.9 ) Pub Date : 2020-01-15 , DOI: 10.1371/journal.pone.0227696 Sergio Cordovilla-Guardia 1, 2 , Tania Bautista Molina 3 , Cristina Franco-Antonio 1, 2 , Esperanza Santano-Mogena 1, 2 , Raquel Vilar-López 4, 5
Affiliation
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INTRODUCTION
The relationship between benzodiazepines, opioids and tricyclic antidepressants and trauma is of great importance because of increased consumption and the growing evidence of a positive association among older adults. The objective of this study was to determine the effect size of the association between the consumption of psychotropic medications /opioids and falls in patients who have suffered trauma by studying the role of other variables in this relationship.
METHOD
From 2011 to 2016, the presence of benzodiazepines, opioids and tricyclic antidepressants and other drugs in 1060 patients admitted for trauma at a level I trauma hospital was analysed. Multivariate models were used to measure the adjusted effect size of the association between consumption of benzodiazepines, opioids and tricyclic antidepressants and falls, and the effect of age on this association was studied.
RESULTS
A total of 192 patients tested positive for benzodiazepines, opioids and tricyclic antidepressants, with same-level falls being the most frequent mechanism of injury in this group (40.1%), with an odds ratio of 1.96 (1.40-2.75), p < 0.001. Once other covariates were introduced, this association was not observed, leaving only age, gender (woman) and, to a lesser extent, sensory conditions as variables associated with falls. Age acted as an effect modifier between benzodiazepines, opioids and tricyclic antidepressants and falls, with significant effect sizes starting at 51.9 years of age.
CONCLUSIONS
The association between the consumption of benzodiazepines, opioids and tricyclic antidepressants and falls in patients admitted for trauma is conditioned by other confounding variables, with age being the most influential confounding variable.
中文翻译：
苯二氮卓类药物、阿片类药物和三环类抗抑郁药的使用与创伤患者跌倒的关联：年龄的条件影响。
引言 由于苯二氮卓类药物、阿片类药物和三环类抗抑郁药与创伤之间的关系非常重要，因为消费量增加，而且越来越多的证据表明老年人之间存在正相关关系。本研究的目的是通过研究其他变量在这种关系中的作用，确定精神药物/阿片类药物的消耗与遭受创伤的患者跌倒之间的关联效应大小。方法对2011年至2016年某创伤一级医院收治的1060例创伤患者体内苯二氮卓类、阿片类药物和三环类抗抑郁药等药物的使用情况进行分析。使用多变量模型来测量苯二氮卓类药物、阿片类药物和三环类抗抑郁药的消费与跌倒之间关联的调整效应大小，并研究了年龄对此关联的影响。结果 共有 192 名患者苯二氮卓类药物、阿片类药物和三环类抗抑郁药检测呈阳性，同水平跌倒是该组中最常见的损伤机制 (40.1%)，比值比为 1.96 (1.40-2.75)，p % 3C 0.001。一旦引入其他协变量，就没有观察到这种关联，只剩下年龄、性别（女性）以及较小程度的感觉条件作为与跌倒相关的变量。年龄是苯二氮卓类药物、阿片类药物和三环类抗抑郁药与跌倒之间的效应调节剂，从 51.9 岁开始，效应大小显着。结论 苯二氮卓类药物、阿片类药物和三环类抗抑郁药的服用量与因创伤入院的患者跌倒之间的关联受到其他混杂变量的影响，其中年龄是最有影响力的混杂变量。
更新日期：2020-01-16
中文翻译：
苯二氮卓类药物、阿片类药物和三环类抗抑郁药的使用与创伤患者跌倒的关联：年龄的条件影响。
引言 由于苯二氮卓类药物、阿片类药物和三环类抗抑郁药与创伤之间的关系非常重要，因为消费量增加，而且越来越多的证据表明老年人之间存在正相关关系。本研究的目的是通过研究其他变量在这种关系中的作用，确定精神药物/阿片类药物的消耗与遭受创伤的患者跌倒之间的关联效应大小。方法对2011年至2016年某创伤一级医院收治的1060例创伤患者体内苯二氮卓类、阿片类药物和三环类抗抑郁药等药物的使用情况进行分析。使用多变量模型来测量苯二氮卓类药物、阿片类药物和三环类抗抑郁药的消费与跌倒之间关联的调整效应大小，并研究了年龄对此关联的影响。结果 共有 192 名患者苯二氮卓类药物、阿片类药物和三环类抗抑郁药检测呈阳性，同水平跌倒是该组中最常见的损伤机制 (40.1%)，比值比为 1.96 (1.40-2.75)，p % 3C 0.001。一旦引入其他协变量，就没有观察到这种关联，只剩下年龄、性别（女性）以及较小程度的感觉条件作为与跌倒相关的变量。年龄是苯二氮卓类药物、阿片类药物和三环类抗抑郁药与跌倒之间的效应调节剂，从 51.9 岁开始，效应大小显着。结论 苯二氮卓类药物、阿片类药物和三环类抗抑郁药的服用量与因创伤入院的患者跌倒之间的关联受到其他混杂变量的影响，其中年龄是最有影响力的混杂变量。
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