BACKGROUND Cannabis use and major depressive disorder (MDD) are common and often co-morbid in adolescents, but the nature and directionality of the relationship between these two conditions remains obscure. METHODS We examined results from the National Survey on Drug Use and Health. Weighted demographics were compared between adolescents with a history of cannabis use (N = 14,873) and never users (N = 73,079). Weighted logistic regression controlling for demographic variables and other substance use was used to determine the relationship between cannabis use frequency and MDD. RESULTS Adolescents with any history of cannabis use had significantly higher rates of lifetime and past year MDD, MDD with severe role impairment, and past year suicide attempt (p < 0.001). Comparing use frequency groups in the adjusted model revealed that heavy users (weekly or greater use) had significantly lower predicted prevalence of lifetime and past year MDD, and past year MDD with severe role impairment compared to light users and those who used cannabis >1 year ago. Rates of reported past year suicide attempt did not differ significantly by cannabis use frequency. CONCLUSIONS Adolescents with any cannabis use history have significantly higher rates of MDD. However, the directionality between frequency of use and MDD is counter to what was expected.

中文翻译：

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青少年大麻使用频率与重度抑郁症之间的关系：2012-2017 年全国药物使用和健康调查的结果。


背景大麻使用和重度抑郁症（MDD）在青少年中很常见，并且常常同时发病，但这两种疾病之间关系的性质和方向性仍然不清楚。方法 我们检查了全国药物使用和健康调查的结果。对有吸食大麻史的青少年 (N = 14,873) 和从未吸食大麻的青少年 (N = 73,079) 进行了加权人口统计数据比较。使用控制人口变量和其他物质使用的加权逻辑回归来确定大麻使用频率与 MDD 之间的关系。结果 有大麻使用史的青少年终生和过去一年的 MDD、严重角色障碍的 MDD 以及过去一年的自杀企图率显着较高 (p < 0.001)。比较调整模型中的使用频率组显示，与轻度使用者和使用大麻的人相比，重度使用者（每周或更多使用）的终生和过去一年 MDD 的预测患病率显着较低，过去一年 MDD 具有严重的角色障碍 >1 年前。去年报告的自杀未遂率因大麻使用频率的不同而没有显着差异。结论 有任何大麻使用史的青少年患重度抑郁症的几率明显更高。然而，使用频率和 MDD 之间的方向性与预期相反。