Individuals who received the hepatitis B vaccine series as young children are entering the healthcare workforce. Our study measured the persistence of antibody to the hepatitis B surface antigen (anti-HBs) at time of employment. Among 986 individuals born in 1991 or more recently with documentation of completion of the hepatitis B vaccine series, 51% had anti-HBs < 10mIU/ml. Of these 507 healthcare workers, 446 (88%) received documented fourth dose of hepatitis B vaccine followed by another anti-HBs ≥ 28 days post vaccination; 11% (50/446 or 5% of the total population) did not mount an anamnestic response. The non-responders were more likely to be male or complete the vaccine series prior to age 7 months. Measuring anti-HBs at the time of hire in this population of healthcare workers who had documentation of hepatitis B series completion as young children may be unnecessary because of the high rate of hepatitis B vaccine protection.

中文翻译：

---

威斯康星州一家学术医学中心的儿童免疫接种的医护人员中乙型肝炎抗体状况的横断面研究。

年幼时接受过乙型肝炎疫苗接种的个人正在进入医疗保健队伍。我们的研究测量了就业时针对乙型肝炎表面抗原（抗HBs）的抗体的持久性。在1991年或更早出生的有完成乙型肝炎疫苗系列记录的个体中，有51％的抗HBs <10mIU / ml。在这507名医护人员中，有446名（88％）接受了有记录的第四次乙型肝炎疫苗接种，随后又接种了≥28天的抗HBs。11％（50/446或总人口的5％）没有记忆消除反应。无反应者更可能是男性或在7个月大之前完成了疫苗系列。