Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, XpertⓇMTB/RIF.,Journal of Infection

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Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, XpertⓇMTB/RIF.
Journal of Infection ( IF 14.3 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.jinf.2019.12.023
Daniel Camprubí ₁ , Aina Gomila ₂ , Maria D Grijota-Camino ₃ , Laura Soldevila ₃ , Maria J Luque ₃ , Fernando Alcaide ₄ , Jordi Dorca ₅ , Miguel Santin ₆

Affiliation

Tuberculosis Unit, Infectious Disease Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, c/ de la Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Barcelona, Spain; ISGlobal, Hospital Clínic - University of Bercelona, Barcelona, Spain.
Tuberculosis Unit, Infectious Disease Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, c/ de la Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Barcelona, Spain; Infectious Diseases Department, Hospital Universitari Parc Taulí, Sabadell, Barcelona, Spain.
Tuberculosis Unit, Infectious Disease Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, c/ de la Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
Microbiology Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain; Respirology Service, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Tuberculosis Unit, Infectious Disease Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, c/ de la Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Barcelona, Spain; University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

Currently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p = 0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (XpertⓇMTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation.

中文翻译：

实时聚合酶链反应，XpertⓇMTB/ RIF评估涂片阴性肺结核患者的感染性。

目前，肺结核（TB）隔离建议基于连续痰涂片显微镜检查。为了评估涂片阴性/ GeneXpert阳性（Sm- / GXpert +）肺结核的传染性，我们评估了在西班牙一家教学医院就诊的511例肺结核患者的接触情况（2010-2018年）。结核分枝杆菌感染率无统计学差异（涂片阳性接触率为46.2％，Sm- / GXpert +肺结核患者接触率为34.6％，p = 0.112）。Sm- / GXpert +肺结核具有结核分枝杆菌感染传播的巨大风险。我们的结果为包括实时聚合酶链反应（XpertⓇMTB/ RIF）在内的可疑肺结核病例的诊断诊断提供了证据，以决定是否进行空气传播隔离。

更新日期：2020-01-16

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