High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials.,Advanced Materials

当前位置： X-MOL 学术 › Adv. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-01-16 , DOI: 10.1002/adma.201903862
Stuart G Higgins _{1,

2} , Michele Becce ₁ , Alexis Belessiotis-Richards ₁ , Hyejeong Seong _{1,

2} , Julia E Sero _{1,

2} , Molly M Stevens _{1,

2,

3}

Affiliation

Materials patterned with high-aspect-ratio nanostructures have features on similar length scales to cellular components. These surfaces are an extreme topography on the cellular level and have become useful tools for perturbing and sensing the cellular environment. Motivation comes from the ability of high-aspect-ratio nanostructures to deliver cargoes into cells and tissues, access the intracellular environment, and control cell behavior. These structures directly perturb cells' ability to sense and respond to external forces, influencing cell fate, and enabling new mechanistic studies. Through careful design of their nanoscale structure, these systems act as biological metamaterials, eliciting unusual biological responses. While predominantly used to interface eukaryotic cells, there is growing interest in nonanimal and prokaryotic cell interfacing. Both experimental and theoretical studies have attempted to develop a mechanistic understanding for the observed behaviors, predominantly focusing on the cell-nanostructure interface. This review considers how high-aspect-ratio nanostructured surfaces are used to both stimulate and sense biological systems.

中文翻译：

作为生物超材料的高纵横比纳米结构表面。

采用高纵横比纳米结构图案的材料具有与细胞组件相似的长度尺度的特征。这些表面是细胞水平上的极端地形，已成为扰动和感知细胞环境的有用工具。动机来自于高纵横比纳米结构将货物输送到细胞和组织、进入细胞内环境和控制细胞行为的能力。这些结构直接扰乱细胞感知和响应外力的能力，影响细胞命运，并促进新的机制研究。通过精心设计纳米级结构，这些系统充当生物超材料，引发不寻常的生物反应。虽然主要用于连接真核细胞，但人们对非动物和原核细胞连接的兴趣越来越大。实验和理论研究都试图对观察到的行为形成机制理解，主要集中在细胞-纳米结构界面。这篇综述考虑了如何使用高纵横比纳米结构表面来刺激和感知生物系统。

更新日期：2020-03-03

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11