Similar to patients with cystic fibrosis (CF) and non-CF bronchiectasis, patients with primary ciliary dyskinesia (PCD) are prone to recurrent or chronic lung infections with Pseudomonas aeruginosa. Chronic P. aeruginosa lung infection has a prevalence of up to 39% in patients with PCD [1] and is associated with structural damage, affecting lung function. Treatment of P. aeruginosa infection is challenging because P. aeruginosa adapts to the host environment through genotypic/phenotypic changes, promoting a reduced immune response [2]. For the first time it is shown that the same Pseudomonas aeruginosa clone exists in both the upper and lower airways in patients with PCD, providing a solid support of the unified airway theory where the sinuses are a possible bacterial reservoir http://bit.ly/2kcE9tq

中文翻译：

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原发性纤毛运动障碍患者在鼻窦和肺中具有相同的铜绿假单胞菌克隆

与囊性纤维化 (CF) 和非 CF 支气管扩张症患者类似，原发性纤毛运动障碍 (PCD) 患者容易发生铜绿假单胞菌的复发性或慢性肺部感染。慢性铜绿假单胞菌肺部感染在 PCD 患者中的患病率高达 39% [1]，并且与结构损伤相关，影响肺功能。铜绿假单胞菌感染的治疗具有挑战性，因为铜绿假单胞菌通过基因型/表型变化适应宿主环境，促进免疫反应降低 [2]。首次表明在 PCD 患者的上呼吸道和下呼吸道中都存在相同的铜绿假单胞菌克隆，这为统一气道理论提供了坚实的支持，其中鼻窦可能是细菌储存库 http://bit.ly /2kcE9tq