We thank I. Gonda for outlining the promises and challenges of real-life research (RLR), following the publication of the Respiratory Effectiveness Group manifesto in the European Respiratory Journal [1]. As outlined in this correspondence, the ultimate goal of RLR is to improve patients' outcomes through more precise decision-making in the current era of personalised medicine. To this aim, RLR provides evidence complementing randomised controlled trials (RCTs), especially exploring benefit–risk–cost ratios in both large and specific subpopulations, while minimising the Hawthorne effect. I. Gonda underlines a particularly important aspect of RLR, i.e. how it can be revolutionised by new technologies. This is especially promising in the respiratory field, where therapy administered with inhalation devices plays a major role, while many chronic conditions are under the influence of environmental conditions that can now be continuously recorded. Assessment of m-Health tools needs to include high-quality real-life research studies. Reciprocally, real-life research can benefit highly from opportunities offered by connected devices. http://bit.ly/2OK4Fqr

中文翻译：

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关联的现实生活研究，P4 医学的支柱

我们感谢 I. Gonda 在欧洲呼吸杂志 [1] 上发表呼吸有效性小组宣言后概述了现实生活研究 (RLR) 的前景和挑战。正如本文所述，RLR 的最终目标是在当前个性化医疗时代通过更精确的决策来改善患者的预后。为此，RLR 提供了补充随机对照试验 (RCT) 的证据，特别是在大型和特定亚群中探索收益-风险-成本比，同时最大限度地减少霍桑效应。I. Gonda 强调了 RLR 的一个特别重要的方面，即新技术如何革新它。这在呼吸领域尤其有前景，其中吸入装置的治疗起着重要作用，而许多慢性病都受到现在可以连续记录的环境条件的影响。移动健康工具的评估需要包括高质量的现实生活研究。相反，现实生活中的研究可以从连接设备提供的机会中受益匪浅。http://bit.ly/2OK4Fqr