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MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress.
Life Sciences ( IF 5.2 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.lfs.2020.117329 Milad Ashrafizadeh 1 , Zahra Ahmadi 2 , Saeed Samarghandian 3 , Reza Mohammadinejad 4 , Habib Yaribeygi 5 , Thozhukat Sathyapalan 6 , Amirhossein Sahebkar 7
Life Sciences ( IF 5.2 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.lfs.2020.117329 Milad Ashrafizadeh 1 , Zahra Ahmadi 2 , Saeed Samarghandian 3 , Reza Mohammadinejad 4 , Habib Yaribeygi 5 , Thozhukat Sathyapalan 6 , Amirhossein Sahebkar 7
Affiliation
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MicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable of preventing oxidative damages by modulating antioxidant defense systems in a variety of milieu, such as in diabetes. Although the exact molecular mechanisms by which miRs modulate the antioxidant defense elements are unclear, some evidence suggests that they may exert these effects via nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This intracellular mechanism is crucial in the maintenance of the physiologic redox balance by regulating the expression and activity of various cellular antioxidative defense elements and thereby plays a pivotal role in the development of oxidative stress. Any impairment in the Nrf2 signaling pathway may result in oxidative damage-dependent complications such as various diabetic complications, neurological disorders and cancer. In the current review, we discuss the modulatory effects of miRs on the Nrf2 signaling pathway, which can potentially be novel therapeutic targets.
中文翻译：
Microrna介导的Nrf2信号通路的调节：在疾病治疗中的意义以及对氧化应激的保护作用。
微小RNA（miR）是小的RNA非编码片段，涉及各种生理过程，例如细胞凋亡，细胞增殖，细胞分化，细胞周期和细胞存活。这些多功能核苷酸还能够通过调节多种环境（例如糖尿病）中的抗氧化剂防御系统来防止氧化损伤。尽管尚不清楚miRs调节抗氧化剂防御元件的确切分子机制，但一些证据表明它们可能通过核因子红系2相关因子2（Nrf2）信号传导途径发挥这些作用。这种细胞内机制通过调节各种细胞抗氧化防御元件的表达和活性，在维持生理氧化还原平衡中至关重要，因此在氧化应激的发展中起着关键作用。Nrf2信号通路中的任何损伤都可能导致依赖氧化损伤的并发症，例如各种糖尿病并发症，神经系统疾病和癌症。在当前的审查中，我们讨论了miRs对Nrf2信号通路的调节作用，这可能是新型治疗靶点。
更新日期：2020-01-16
中文翻译：
Microrna介导的Nrf2信号通路的调节：在疾病治疗中的意义以及对氧化应激的保护作用。
微小RNA（miR）是小的RNA非编码片段，涉及各种生理过程，例如细胞凋亡，细胞增殖，细胞分化，细胞周期和细胞存活。这些多功能核苷酸还能够通过调节多种环境（例如糖尿病）中的抗氧化剂防御系统来防止氧化损伤。尽管尚不清楚miRs调节抗氧化剂防御元件的确切分子机制，但一些证据表明它们可能通过核因子红系2相关因子2（Nrf2）信号传导途径发挥这些作用。这种细胞内机制通过调节各种细胞抗氧化防御元件的表达和活性，在维持生理氧化还原平衡中至关重要，因此在氧化应激的发展中起着关键作用。Nrf2信号通路中的任何损伤都可能导致依赖氧化损伤的并发症，例如各种糖尿病并发症，神经系统疾病和癌症。在当前的审查中，我们讨论了miRs对Nrf2信号通路的调节作用，这可能是新型治疗靶点。
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