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Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.
Current Biology ( IF 8.1 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.cub.2019.11.058 Shutang Tan 1 , Melinda Abas 2 , Inge Verstraeten 1 , Matouš Glanc 3 , Gergely Molnár 2 , Jakub Hajný 4 , Pavel Lasák 5 , Ivan Petřík 5 , Eugenia Russinova 6 , Jan Petrášek 7 , Ondřej Novák 5 , Jiří Pospíšil 8 , Jiří Friml 1
Current Biology ( IF 8.1 ) Pub Date : 2020-01-16 , DOI: 10.1016/j.cub.2019.11.058 Shutang Tan 1 , Melinda Abas 2 , Inge Verstraeten 1 , Matouš Glanc 3 , Gergely Molnár 2 , Jakub Hajný 4 , Pavel Lasák 5 , Ivan Petřík 5 , Eugenia Russinova 6 , Jan Petrášek 7 , Ondřej Novák 5 , Jiří Pospíšil 8 , Jiří Friml 1
Affiliation
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Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.
中文翻译：
水杨酸靶向蛋白质磷酸酶2A以减轻植物的生长。
像其他多细胞生物一样，植物通过生长与防御病原体之间的微妙平衡生存。水杨酸（SA）是植物中的主要防御信号，已知激活免疫反应的感知机制以及下游信号传导。在这里，我们确定了介导生长衰减的平行SA信号。SA与蛋白磷酸酶2A（PP2A）的A亚基直接结合，从而抑制了该复合物的活性。在PP2A靶标中，PIN2生长素转运蛋白在响应SA时被过度磷酸化，从而导致该重要生长调节剂的活性发生改变。因此，生长素运输和生长素介导的根发育，包括生长，重力反应和侧根器官发生受到抑制。这项研究揭示了SA除了激活免疫力之外，通过与生长素分配网络的串扰，伴随而减弱了生长。进一步分析SA的双重作用以及表征其他SA调控的PP2A靶标，将对维持生长与防御之间平衡的机制提供进一步的见解。
更新日期：2020-01-16
中文翻译：
水杨酸靶向蛋白质磷酸酶2A以减轻植物的生长。
像其他多细胞生物一样，植物通过生长与防御病原体之间的微妙平衡生存。水杨酸（SA）是植物中的主要防御信号，已知激活免疫反应的感知机制以及下游信号传导。在这里，我们确定了介导生长衰减的平行SA信号。SA与蛋白磷酸酶2A（PP2A）的A亚基直接结合，从而抑制了该复合物的活性。在PP2A靶标中，PIN2生长素转运蛋白在响应SA时被过度磷酸化，从而导致该重要生长调节剂的活性发生改变。因此，生长素运输和生长素介导的根发育，包括生长，重力反应和侧根器官发生受到抑制。这项研究揭示了SA除了激活免疫力之外，通过与生长素分配网络的串扰，伴随而减弱了生长。进一步分析SA的双重作用以及表征其他SA调控的PP2A靶标，将对维持生长与防御之间平衡的机制提供进一步的见解。
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