Enzymes are most efficient catalyst for organic transformations including halogenation of C–H bonds. Most of the halogenating enzymes utilize high valent metal-oxo intermediates for hydrogen atom abstraction (HAA) and subsequent haloalkane formation. Due to high demand of organohalide compounds, many attempts have been made to mimic the active sites of halogenating enzymes in order to achieve efficacy of enzymes. Different first row transition metals complexes have been synthesized using various ligand systems. In this review, we have summarized the efforts made towards development of halogenation using high valent metal-oxo complexes and understanding the mechanism of their activity.

酶是最有效的有机转化催化剂，包括卤化C–H键。大多数卤化酶利用高价金属-氧代中间体生产氢原子（HAA）和随后形成卤代烷烃。由于对有机卤化物的高需求，已经进行了许多尝试来模仿卤化酶的活性位点，以实现酶的功效。已经使用各种配体系统合成了不同的第一排过渡金属络合物。在这篇综述中，我们总结了使用高价金属-氧配合物开发卤化的努力，并了解了其活性机理。