The cooperation between two orthogonal catalytic events during the formation of carbon-carbon and carbon-heteroatom bonds has emerged as an effective strategy for enantioselective chemical synthesis. In recent years, a number of pioneering investigations have described useful chemical synthesis methods whereby the reactivity or nucleophile-electrophile combinations can be fine-tuned or extended far beyond the effect and influence of a single catalyst. The recognition of this has had profound implications for the development cooperative catalysis as a field and has provided a foundation for the development of broadly useful chemical synthesis methods. This chapter focuses on the combination of tertiary amine Lewis base and transition metal catalysts, which the authors hope will simulate further developments and advances.

中文翻译：

---

与过渡金属催化结合的叔胺路易斯碱催化。

在碳-碳和碳-杂原子键形成过程中，两个正交催化事件之间的合作已成为对映选择性化学合成的有效策略。近年来，许多开创性研究已经描述了有用的化学合成方法，由此可以对反应性或亲核试剂-亲电子试剂的组合进行微调或扩展，使其远远超出单一催化剂的作用和影响。对此的认识对于发展合作催化这一领域具有深远的意义，并为开发广泛有用的化学合成方法提供了基础。本章着重于叔胺路易斯碱和过渡金属催化剂的组合，作者希望这些组合将模拟进一步的发展和进步。