CRISPR-Cas9 engineered CYBB^ko THP-1 cell lines display an inflammatory profile with increased IL-1β, IL-6 and TNF-α secretion as consequence of NADPH-induced ROS deficiency. This phenotype is reminiscent of the one observed in phagocytes from CGD patients.

中文翻译：

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CRISPR基因工程化的CYBBko THP-1细胞系突显了NADPH诱导的活性氧在调节炎症小体活化中的关键作用。

CRISPR-Cas9工程化的CYBB ^ko THP-1细胞系显示出炎症反应，其NADPH诱导的ROS缺乏导致IL-1β，IL-6和TNF-α分泌增加。这种表型让人联想到在CGD患者的吞噬细胞中观察到的一种表型。