Porphyrin-based porous organic polymers are highly potential candidates for cancer theranostics. However, un-controllable particle size and unclear photoactive mechanisms have been deemed to be "Achilles' heels" for their biomedical application. Herein, a facile self-template strategy has been applied to integrate two types of porous materials to build the MOF@POP-PEG nanocomposite (named HUC-PEG). As-synthesized HUC-PEG exhibited controllable particle shape and size, good biocompatibility, and better colloidal stability. Importantly, synergy "0 + 1 > 1" interface effects have been demonstrated to simultaneously enhance both the generation of more singlet oxygen (1O2) for photodynamic therapy (PDT) and local hyperthermia for photothermal therapy (PTT), thus to achieve favorable proliferation inhibition of tumor cell both in vitro and in vivo. Moreover, the strong X-ray attenuating ability of Hf element and excellent photothermal conversion efficacy endow this nanocomposite with computed tomography (CT)/photothermal imaging functions. We believe that our ingenious design may open a new horizon for the preparation of nanoscale POP-based therapeutic agents and also realize a paradigm shift in the understanding of photoactive mechanism in porous materials.

中文翻译：

---

金属有机骨架与光敏多孔有机聚合物的结合，用于界面增强的光疗。

卟啉基多孔有机聚合物是癌症治疗学的高度潜在候选人。然而，对于其生物医学应用而言，不可控制的粒径和不清楚的光敏机制被认为是“致命弱点”。本文中，已经应用了一种简便的自我模板策略来整合两种类型的多孔材料，以构建MOF @ POP-PEG纳米复合材料（称为HUC-PEG）。合成后的HUC-PEG表现出可控的颗粒形状和大小，良好的生物相容性和更好的胶体稳定性。重要的是，协同效应“ 0 +1> 1”的界面效应已被证明可以同时增强光动力疗法（PDT）和单线局部热疗（PTT）的更多单线态氧（1O2）的产生，因此在体外和体内都实现了对肿瘤细胞有利的增殖抑制。此外，H元素具有强大的X射线衰减能力和出色的光热转换功效，使这种纳米复合材料具有计算机断层扫描（CT）/光热成像功能。我们相信，我们的巧妙设计可能会为纳米级基于POP的治疗剂的制备开辟新的视野，并且还将实现对多孔材料中光敏机理的理解的范式转变。