Fabrication of smart stimuli-responsive mesoporous organosilica nano-vehicles for targeted pesticide delivery.,Journal of Hazardous Materials

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Fabrication of smart stimuli-responsive mesoporous organosilica nano-vehicles for targeted pesticide delivery.
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2020-01-15 , DOI: 10.1016/j.jhazmat.2020.122075
You Liang ₁ , Yunhao Gao ₁ , Weichen Wang ₁ , Hongqiang Dong ₁ , Rong Tang ₁ , Jiale Yang ₁ , Junfan Niu ₁ , Zhiyuan Zhou ₁ , Na Jiang ₁ , Yongsong Cao ₁

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It is highly desirable to construct stimuli-responsive nanocarriers for improving pesticides targeting and preventing the pesticides premature release. In this work, a novel redox and α-amylase dual stimuli-responsive pesticide delivery system was established by bonding functionalized starch with biodegradable disulfide-bond-bridged mesoporous silica nanoparticles which loaded with avermectin (avermectin@MSNs-ss-starch nanoparticles). The results demonstrated that the loading capacity of avermectin@MSNs-ss-starch nanoparticles for avermectin was approximately 9.3 %. The starch attached covalently on the mesoporous silica nanoparticles could protect avermectin from photodegradation and prevent premature release of active ingredient. Meanwhile, the coated starch and disulfide-bridged structure of nanoparticles could be decomposed and consequently release of the avermectin on demand when nanoparticles were metabolized by glutathione and α-amylase in insects. The bioactivity survey confirmed that avermectin@MSNs-ss-starch nanoparticles had a longer duration in controlling Plutella xylostella larvae compared to avermectin emulsifiable concentrate. In consideration of the superior insecticidal activity and free of toxic organic solvent, this target-specific pesticide release system has promising potential in pest management.

中文翻译：

制备用于目标农药传递的智能刺激响应介孔有机硅纳米车辆。

迫切需要构建刺激响应性纳米载体，以改善农药靶向性并防止农药过早释放。在这项工作中，通过将功能化淀粉与负载有阿维菌素的可生物降解的二硫键桥联介孔二氧化硅纳米粒子（avermectin @ MSNs-ss-淀粉纳米粒子）结合在一起，建立了一种新型的氧化还原和α-淀粉酶双重刺激响应农药传递系统。结果表明，阿维菌素@ MSNs-ss-淀粉纳米粒子对阿维菌素的负载量约为9.3％。共价附着在中孔二氧化硅纳米颗粒上的淀粉可以保护阿维菌素免受光降解并防止活性成分过早释放。与此同时，当昆虫体内的谷胱甘肽和α-淀粉酶代谢纳米粒子时，纳米粒子的包覆淀粉和二硫键桥接结构可能会分解，从而按需释放阿维菌素。生物活性调查证实，与阿维菌素乳油相比，阿维菌素@ MSNs-ss淀粉纳米颗粒在控制小菜蛾幼虫中的持续时间更长。考虑到优异的杀虫活性，并且不含有毒有机溶剂，这种针对特定目标的农药释放系统在有害生物管理方面具有广阔的前景。生物活性调查证实，与阿维菌素乳油相比，阿维菌素@ MSNs-ss淀粉纳米颗粒在控制小菜蛾幼虫中的持续时间更长。考虑到优异的杀虫活性，并且不含有毒有机溶剂，这种针对特定目标的农药释放系统在有害生物管理方面具有广阔的前景。生物活性调查证实，与阿维菌素乳油相比，阿维菌素@ MSNs-ss淀粉纳米颗粒在控制小菜蛾幼虫中的持续时间更长。考虑到优异的杀虫活性，并且不含有毒有机溶剂，这种针对特定目标的农药释放系统在有害生物管理方面具有广阔的前景。

更新日期：2020-01-15

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