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Three-dimensionally printed polylactic acid/cellulose acetate scaffolds with antimicrobial effect
RSC Advances ( IF 3.9 ) Pub Date : 2020-1-15 , DOI: 10.1039/c9ra08916k Mengdi Zuo 1 , Nengyu Pan 1 , Quanjing Liu 2 , Xuehong Ren 1 , Yu Liu 2 , Tung-Shi Huang 3
RSC Advances ( IF 3.9 ) Pub Date : 2020-1-15 , DOI: 10.1039/c9ra08916k Mengdi Zuo 1 , Nengyu Pan 1 , Quanjing Liu 2 , Xuehong Ren 1 , Yu Liu 2 , Tung-Shi Huang 3
Affiliation
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This study aimed to develop novel, biodegradable, antiseptic-loaded and low-cost scaffolds using a direct ink writing (DIW) technique for antibacterial applications. Polylactic acid/cellulose acetate (PLA/CA) mixtures with different composition ratios were prepared, and the effect of CA content on the rheological behaviors of the inks was investigated. The printability of the prepared DIW inks was improved with the addition of the appropriate amount of CA, since the formation of hydrogen bonding 3D network between PLA and CA. As a result, a liquid form ink consisting of majority of PLA and minority of CA which was prepared and printed for the first time through DIW technique. Afterwards, the antimicrobial agent, 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (MC) was incorporated into the inks for preventing bacterial infections, which showed excellent stability and effective antibacterial activity against S. aureus and E. coli O157:H7 in a short time. Owning the ease of fabrication and the biocidal property, our 3D printed scaffolds will have a wide range of potential applications in the field of food packaging, communal facilities, medical equipments, and biomedical materials.
中文翻译：
具有抗菌作用的三维打印聚乳酸/醋酸纤维素支架
本研究旨在使用直接墨水书写 (DIW) 技术开发用于抗菌应用的新型、可生物降解、防腐剂和低成本支架。制备了不同组成比的聚乳酸/醋酸纤维素（PLA/CA）混合物，研究了CA含量对油墨流变行为的影响。由于 PLA 和 CA 之间形成了氢键 3D 网络，通过添加适量的 CA，制备的 DIW 油墨的可印刷性得到改善。结果，通过DIW技术首次制备和印刷了由大部分PLA和少量CA组成的液体形式墨水。之后，将抗菌剂 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (MC) 加入到墨水中以防止细菌感染，S. aureus和E. coli O157:H7 在短时间内。我们的 3D 打印支架具有易于制造和杀菌性能，将在食品包装、公共设施、医疗设备和生物医学材料领域具有广泛的潜在应用。
更新日期：2020-01-15
中文翻译：
具有抗菌作用的三维打印聚乳酸/醋酸纤维素支架
本研究旨在使用直接墨水书写 (DIW) 技术开发用于抗菌应用的新型、可生物降解、防腐剂和低成本支架。制备了不同组成比的聚乳酸/醋酸纤维素（PLA/CA）混合物，研究了CA含量对油墨流变行为的影响。由于 PLA 和 CA 之间形成了氢键 3D 网络，通过添加适量的 CA，制备的 DIW 油墨的可印刷性得到改善。结果，通过DIW技术首次制备和印刷了由大部分PLA和少量CA组成的液体形式墨水。之后，将抗菌剂 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (MC) 加入到墨水中以防止细菌感染，S. aureus和E. coli O157:H7 在短时间内。我们的 3D 打印支架具有易于制造和杀菌性能，将在食品包装、公共设施、医疗设备和生物医学材料领域具有广泛的潜在应用。
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