Tetraphenylporphine-Modified Polymeric Nanoparticles Containing NIR Photosensitizer for Mitochondria-Targeting and Imaging-Guided Photodynamic Therapy,ACS Biomaterials Science & Engineering

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Tetraphenylporphine-Modified Polymeric Nanoparticles Containing NIR Photosensitizer for Mitochondria-Targeting and Imaging-Guided Photodynamic Therapy
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-01-23 , DOI: 10.1021/acsbiomaterials.9b01662
Pan Yuan ₁ , Zheng Ruan ₁ , Lifeng Yan ₁

Affiliation

Near-infrared (NIR) photodynamic therapy (PDT) is a promising antitumor strategy under NIR light irradiation to kill cancer cells. Mitochondria has a critical function in sustaining cellular viability and death, which is the ideal organelle for PDT. Here, we reported a tetraphenylporphine (TPP)-conjugated amphiphilic copolymer and an iodinated boron dipyrromethene photosensitizer (BDPI) with high singlet oxygen yield to form nanoparticles (PBDPI-TPP), which could realize mitochondria-targeting and improve the NIR imaging-guided PDT. The as-prepared mitochondria-targeting nanoplatform could show effective subcellular localization and bring about significant irreversible mitochondrial injury for enhanced PDT. Both in vitro and in vivo experiments revealed that the mitochondria-targeting PDT system could achieve a remarkable therapeutic effect, indicating that it is a promising nanoplatform for NIR imaging-guided PDT in cancer therapeutics.

中文翻译：

含NIR光敏剂的四苯基卟啉修饰的聚合物纳米颗粒用于线粒体靶向和成像引导的光动力疗法

近红外（NIR）光动力疗法（PDT）是一种在NIR光照射下杀死癌细胞的有前途的抗肿瘤策略。线粒体在维持细胞活力和死亡方面具有关键作用，这是PDT的理想细胞器。在这里，我们报道了四苯基卟啉（TPP）共轭的两亲共聚物和碘化硼二吡咯亚甲基光敏剂（BDPI），具有高单线态氧产量以形成纳米颗粒（PBDPI-TPP），可以实现线粒体靶向并改善NIR成像引导的PDT 。制备的靶向线粒体的纳米平台可以显示有效的亚细胞定位，并为增强PDT带来重大不可逆的线粒体损伤。体外和体内实验均表明，靶向线粒体的PDT系统可以达到显着的治疗效果，

更新日期：2020-01-23

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