Bacterial cellulose (BC) membranes display special properties and structures, thus attracting much attention in application in the biomedical areas, for example, as implants for bone or cartilage tissue engineering, as substitutes for skin repairing, and as supports for controlled drug delivery. However, native BC lacks the activity to inhibit bacteria growth on its surface, which limits its applications in biomedical fields. There have been reports on chemical modification of BC membranes to endow them with antimicrobial properties needed for some special biomedical applications. In the present study, aminoalkyl‐grafted BC membranes were prepared by alkoxysilane polycondensation using 3‐aminopropyltriethoxysilane (APTES). The characterization for morphology and chemical composition showed that BC membranes were successfully grafted with aminoalkylsilane groups through covalent bonding. The surface morphology and roughness of the membranes changed after chemical grafting. Furthermore, after grafting with APTES, the membranes got less hydrophilic than native BC. The aminoalkyl‐grafted BC membranes showed strong antibacterial properties against Staphylococcus aureus and Escherichia coli and moreover, they were nontoxic to normal human dermal fibroblasts. These results indicate that aminoalkyl‐grafted BC membranes are potential to be used for biomedical applications.

中文翻译：

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用于生物医学应用的具有改进的抗菌性能的氨基烷基接枝细菌纤维素膜的制备。

细菌纤维素（BC）膜显示出特殊的性质和结构，因此在生物医学领域的应用备受关注，例如，作为骨或软骨组织工程的植入物，作为皮肤修复的替代品，以及作为控制药物递送的支持。然而，天然BC缺乏抑制其表面细菌生长的活性，这限制了其在生物医学领域的应用。有报道称，对 BC 膜进行化学改性，使其具有某些特殊生物医学应用所需的抗菌特性。在本研究中，使用 3-氨基丙基三乙氧基硅烷 (APTES) 通过烷氧基硅烷缩聚制备氨基烷基接枝 BC 膜。形态和化学成分的表征表明，BC 膜通过共价键成功接枝了氨基烷基硅烷基团。化学接枝后膜的表面形态和粗糙度发生了变化。此外，在用 APTES 接枝后，膜的亲水性低于天然 BC。氨基烷基接枝的 BC 膜对金黄色葡萄球菌和大肠杆菌，此外，它们对正常人真皮成纤维细胞无毒。这些结果表明氨基烷基接枝的 BC 膜具有用于生物医学应用的潜力。