Accurate quantitative analysis of bromine and iodine in serum is an important aspect of monitoring body condition, but the volatile loss of halogen in sample pretreatment is a troublesome problem. We present a validated and flexible high‐throughput method for quantification of bromine and iodine in dried serum spots (DSS) using laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS) and an external aqueous standard calibration curve. The influence of serum matrix and laser ablation (LA) conditions on the analysis of bromine and iodine in DSS was researched systematically.

中文翻译：

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激光消融电感耦合等离子体质谱法直接分析干燥血清斑点中的溴和碘

准确定量分析血清中的溴和碘是监测人体状况的重要方面，但是样品预处理中卤素的挥发损失是一个麻烦的问题。我们提供了一种经过验证且灵活的高通量方法，可使用激光消融电感耦合等离子体质谱仪（LA-ICP-MS）和外部水标准校准曲线对干血清斑点（DSS）中的溴和碘进行定量。系统研究了血清基质和激光烧蚀条件对DSS中溴和碘分析的影响。