One-Pot Synthesis of Fe/N-Doped Hollow Carbon Nanospheres with Multienzyme Mimic Activities against Inflammation,ACS Applied Bio Materials

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One-Pot Synthesis of Fe/N-Doped Hollow Carbon Nanospheres with Multienzyme Mimic Activities against Inflammation
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-24 , DOI: 10.1021/acsabm.9b01079
Lei Fan ₁ , Peizheng Sun ₁ , Yaling Huang ₂ , Zhilong Xu ₁ , Ximing Lu ₁ , Juqun Xi ₂ , Jie Han ₁ , Rong Guo ₁

Affiliation

Inflammation, including infectious and noninfectious inflammation, are a growing threat to public health worldwide. For different types of inflammation, more specific and intensified therapy is needed. Nanozymes are able to regulate levels of radical reactive oxygen species (ROS) to suppress inflammation, becoming potential anti-inflammatory agents. Herein, hollow porous carbon spheres codoped with nitrogen and iron (Fe/N-HCNs) are synthesized through a one-pot strategy, which exerted multienzyme mimicking activities, including peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, and superoxide dismutase (SOD)-like activities. Moreover, these activities were promoted by the removal of iron oxides produced in the synthesis process. Based on the study of multienzyme activities, we designed two kinds of animal inflammatory models, bacteria-infected wound and inflammatory bowel disease, to evaluate the anti-inflammation ability of Fe/N-HCNs. The results indicated that Fe/N-HCNs could increase ROS levels through performing their POD-like activity in a weak acid environment to catalyze H₂O₂ against bacteria-infected wound healing, whereas Fe/N-HCNs with the capability of scavenging ROS in a neutral environment could also be unitized to treat noninfectious inflammatory bowel disease. Together, our study provided evidence that the prominent multienzyme activities of Fe/N-HCNs could be used as an anti-inflammatory alternative for both infectious and noninfectious inflammation.

中文翻译：

一锅法合成具有多酶模拟活性的 Fe/N 掺杂空心碳纳米球

炎症，包括传染性和非传染性炎症，对全世界的公共卫生构成日益严重的威胁。对于不同类型的炎症，需要更具体和强化的治疗。纳米酶能够调节自由基活性氧 (ROS) 的水平以抑制炎症，成为潜在的抗炎剂。在此，通过一锅法合成了与氮和铁共掺杂的中空多孔碳球（Fe/N-HCNs），其发挥多酶模拟活性，包括过氧化物酶（POD）-、氧化酶（OXD）-、过氧化氢酶（CAT） - 和超氧化物歧化酶 (SOD) 样活性。此外，通过去除合成过程中产生的氧化铁促进了这些活动。基于对多酶活性的研究，我们设计了两种动物炎症模型，细菌感染的伤口和炎症性肠病，以评估 Fe/N-HCNs 的抗炎能力。结果表明，Fe/N-HCNs可以通过在弱酸环境中表现出类似POD的活性来催化H₂ O ₂对抗细菌感染的伤口愈合，而具有在中性环境中清除 ROS 能力的 Fe/N-HCNs 也可以联合用于治疗非感染性炎症性肠病。总之，我们的研究提供了证据，表明 Fe/N-HCN 的突出多酶活性可用作感染性和非感染性炎症的抗炎替代品。

更新日期：2020-01-24

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