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Near-Infrared Conjugated Oligomer for Effective Killing of Bacterial through Combination of Photodynamic and Photothermal Treatment
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-22 , DOI: 10.1021/acsabm.9b01242 Rui Peng 1 , Yufeng Luo 1 , Qianling Cui 1 , Jun Wang 1 , Lidong Li 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-01-22 , DOI: 10.1021/acsabm.9b01242 Rui Peng 1 , Yufeng Luo 1 , Qianling Cui 1 , Jun Wang 1 , Lidong Li 1
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In recent years, phototherapeutic strategies including photodynamic therapy (PDT) and photothermal treatment (PTT) have attracted extensive interest in biological and medical applications. To achieve high efficiency in therapy, it is crucial to develop promising agents possessing synergistic PDT and PTT effects, especially those triggered by single-wavelength near-infrared (NIR) light. Herein, a low-bandgap fluorene-based conjugated oligomer OF-Green-N with a donor–acceptor–donor (D–A–D) structure was synthesized, which had a broad absorption in both the visible and NIR range. Upon irradiation by 808 nm laser, the oligomer displayed a good photothermal capacity with a conversion efficiency of 37.7%, together with simultaneous photodynamic behavior which produced reactive oxygen species. By incubation with Escherichia coli, OF-Green-N was demonstrated to possess outstanding antibacterial activity owing to the synergistic effects of PDT/PTT. Moreover, its green fluorescence excited by 420 nm light also provides an opportunity for imaging-guided treatment.
中文翻译：
近红外共轭低聚物结合光动力和光热处理有效杀灭细菌
近年来，包括光动力疗法（PDT）和光热疗法（PTT）在内的光疗策略在生物和医学应用中引起了广泛的兴趣。为了实现高效率的治疗，开发具有协同 PDT 和 PTT 效应的有前景的药物至关重要，尤其是那些由单波长近红外 (NIR) 光触发的药物。在此，合成了一种具有供体-受体-供体（D-A-D）结构的低带隙芴基共轭低聚物OF-Green-N，它在可见光和近红外范围内均具有广泛的吸收。在 808 nm 激光照射下，低聚物显示出良好的光热容量，转换效率为 37.7%，同时具有产生活性氧的光动力学行为。通过与大肠杆菌孵育, 由于 PDT/PTT 的协同作用, OF-Green-N 被证明具有出色的抗菌活性。此外，其由 420 nm 光激发的绿色荧光也为成像引导治疗提供了机会。
更新日期：2020-01-23
中文翻译：
近红外共轭低聚物结合光动力和光热处理有效杀灭细菌
近年来，包括光动力疗法（PDT）和光热疗法（PTT）在内的光疗策略在生物和医学应用中引起了广泛的兴趣。为了实现高效率的治疗，开发具有协同 PDT 和 PTT 效应的有前景的药物至关重要，尤其是那些由单波长近红外 (NIR) 光触发的药物。在此，合成了一种具有供体-受体-供体（D-A-D）结构的低带隙芴基共轭低聚物OF-Green-N，它在可见光和近红外范围内均具有广泛的吸收。在 808 nm 激光照射下，低聚物显示出良好的光热容量，转换效率为 37.7%，同时具有产生活性氧的光动力学行为。通过与大肠杆菌孵育, 由于 PDT/PTT 的协同作用, OF-Green-N 被证明具有出色的抗菌活性。此外，其由 420 nm 光激发的绿色荧光也为成像引导治疗提供了机会。
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