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Facial Amphiphilicity-Induced Polymer Nanostructures for Antimicrobial Applications.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-01-15 , DOI: 10.1021/acsami.9b19712 Md Anisur Rahman , Moumita Sharmin Jui , Marpe Bam 1 , Yujin Cha , Edgar Luat , Amjed Alabresm , Mitzi Nagarkatti 1 , Alan W Decho , Chuanbing Tang
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-01-15 , DOI: 10.1021/acsami.9b19712 Md Anisur Rahman , Moumita Sharmin Jui , Marpe Bam 1 , Yujin Cha , Edgar Luat , Amjed Alabresm , Mitzi Nagarkatti 1 , Alan W Decho , Chuanbing Tang
Affiliation
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New antimicrobial agents are needed to address ever-increasing antimicrobial resistance and a growing epidemic of infections caused by multidrug resistant pathogens. We design nanostructured antimicrobial copolymers containing multicyclic natural products that bear facial amphiphilicity. Bile acid based macromolecular architectures of these nanostructures can interact preferentially with bacterial membranes. Incorporation of polyethylene glycol into the copolymers not only improved the colloidal stability of nanostructures but also increased the biocompatibility. This study investigated the effects of facial amphiphilicity, polymer architectures, and self-assembled nanostructures on antimicrobial activity. Advanced nanostructures such as spheres, vesicles, and rod-shaped aggregates are formed in water from the facial amphiphilic cationic copolymers via supramolecular interactions. These aggregates were particularly interactive toward Gram-positive and Gram-negative bacterial cell membranes and showed low hemolysis against mammalian cells.
中文翻译：
用于抗菌应用的面部两亲性诱导聚合物纳米结构。
需要新的抗菌剂来应对不断增长的抗菌剂耐药性以及由多重耐药性病原体引起的感染的流行。我们设计了含有多环天然产物的纳米结构抗菌共聚物，这些天然产物具有面部两亲性。这些纳米结构的基于胆汁酸的大分子结构可以优先与细菌膜相互作用。将聚乙二醇掺入到共聚物中不仅改善了纳米结构的胶体稳定性，而且还提高了生物相容性。这项研究调查了面部两亲性，聚合物结构和自组装纳米结构对抗菌活性的影响。先进的纳米结构，例如球体，囊泡，通过表面两亲性阳离子共聚物通过超分子相互作用在水中形成棒状聚集体。这些聚集体与革兰氏阳性和革兰氏阴性细菌细胞膜特别相互作用，对哺乳动物细胞的溶血性低。
更新日期：2020-01-15
中文翻译：
用于抗菌应用的面部两亲性诱导聚合物纳米结构。
需要新的抗菌剂来应对不断增长的抗菌剂耐药性以及由多重耐药性病原体引起的感染的流行。我们设计了含有多环天然产物的纳米结构抗菌共聚物，这些天然产物具有面部两亲性。这些纳米结构的基于胆汁酸的大分子结构可以优先与细菌膜相互作用。将聚乙二醇掺入到共聚物中不仅改善了纳米结构的胶体稳定性，而且还提高了生物相容性。这项研究调查了面部两亲性，聚合物结构和自组装纳米结构对抗菌活性的影响。先进的纳米结构，例如球体，囊泡，通过表面两亲性阳离子共聚物通过超分子相互作用在水中形成棒状聚集体。这些聚集体与革兰氏阳性和革兰氏阴性细菌细胞膜特别相互作用，对哺乳动物细胞的溶血性低。
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