Tunable Gold(I)-Catalyzed [4 + 3] Cycloaddition for Divergent Synthesis of Furan-Fused N,O-Heterocycles.,Organic Letters

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Tunable Gold(I)-Catalyzed [4 + 3] Cycloaddition for Divergent Synthesis of Furan-Fused N,O-Heterocycles.
Organic Letters ( IF 4.9 ) Pub Date : 2020-01-15 , DOI: 10.1021/acs.orglett.9b04312
Shouzhi Zhang ₁ , Aijie Tang ₁ , Panpan Chen ₁ , Zhiqiang Zhao ₁ , Maozhong Miao ₁ , Hongjun Ren _{1,

2}

Affiliation

By choosing suitable ligand-directed gold catalysts, two types of gold-containing all-carbon 1,4-dipoles could be generated selectively from the gold(I)-catalyzed cycloisomerizations of allenyl ketones bearing a cyclopropyl moiety, which undergo [4 + 3] cycloadditions with nitrones to produce two regiomers of furan-condensed N,O-seven-membered rings in moderate to excellent yields highly selectively.

中文翻译：

可调谐的金（I）催化的[4 + 3]环加成，可合成呋喃熔合的N，O-杂环。

通过选择合适的配体导向金催化剂，可以通过金（I）催化的带有环丙基部分的烯基酮的环异构化反应，选择性地生成两种类型的含金全碳1,4-偶极，它们经历了[4 + 3用硝酮进行环加成反应，可选择性地以中等至极好的产率生成两个呋喃稠合的N，O-七元环的区域异构体。

更新日期：2020-01-15

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