Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins.,European Journal of Immunology

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Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-01-14 , DOI: 10.1002/eji.201948404
Nelli Heikkilä _{1,

2} , Reetta Vanhanen _{1,

2} , Dawit A Yohannes _{1,

3} , Päivi Saavalainen _{1,

3} , Seppo Meri _{1,

2} , T Sakari Jokiranta ₂ , Hanna Jarva ₂ , Ilkka P Mattila ₄ , David Hamm ₅ , Silja Sormunen ₆ , Jari Saramäki ₆ , T Petteri Arstila _{1,

2}

Affiliation

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

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