Enrichment environment conditions, as well as tobacco smoke exposure, may affect cognitive function (e.g. spatial memory) in an animal model of schizophrenia and schizophrenic patients.

The aim of this study was to find whether spatial memory function impairment is found in methylazoxymethanol acetate treated rats (an animal model of schizophrenia) and whether aripiprazole (1.5 mg/kg) and olanzapine (0.5 mg/kg) modify these functions. We also were able to determine whether tobacco smoke exposure and enrichment environment conditions have an impact on drug efficacy.

The effect of methylazoxymethanol acetate, tobacco smoke exposure, enrichment environment and the use of drugs were studied in the Morris Water Maze test (spatial memory).

The results of our study clearly show that enriched environment may have a procognitive effect while tobacco smoke and methylazoxymethanol acetate have a contradictory effect. This paper also confirmed that the use of neuroleptics, namely ARI and OLA, reduced the process of spatial memory deterioration tested in the Morris water maze both in terms of the number of escape latencies and crossed quadrants.

在精神分裂症和精神分裂症患者的动物模型中，丰富的环境条件以及烟草烟雾暴露可能会影响认知功能（例如空间记忆）。

这项研究的目的是发现是否在乙酸甲基乙氧基甲醇酯治疗的大鼠（精神分裂症的动物模型）中发现了空间记忆功能受损，阿立哌唑（1.5 mg / kg）和奥氮平（0.5 mg / kg）是否改变了这些功能。我们还能够确定烟草烟雾暴露和浓缩环境条件是否对药物功效有影响。

在莫里斯水迷宫测试（空间记忆）中研究了乙酸甲基丙氧基甲醇酯，烟草烟雾暴露，富集环境和药物使用的影响。

我们的研究结果清楚地表明，丰富的环境可能具有认知作用，而烟草烟雾和甲基乙氧基甲醇乙酸盐则具有矛盾的作用。本文还确认了使用抗精神病药，即ARI和OLA，可以从逃生潜伏期和交叉象限的角度减少在莫里斯水迷宫中测试的空间记忆退化过程。